Iridium-Catalyzed Selective α-Alkylation of Unactivated Amides with Primary Alcohols

被引：77
|
作者：
Guo, Le [1 ]
Liu, Yinghua [1 ]
Yao, Wubing [1 ]
Leng, Xuebing [1 ]
Huang, Zheng [1 ]
机构：
[1] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 05期
关键词：
PINCER COMPLEX; DEHYDROGENATION; SOLVENT; AMINES;
D O I：
10.1021/ol400360g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first a-alkylation of unactivated amides with primary alcohols is described. An effective and robust iridium pincer complex has been developed for selective alpha-alkylation of tertiary and secondary acetamides involving a "borrowing hydrogen" methodology. The method is compatible with alcohols bearing various functional groups. This presents a convenient and environmentally benign protocol for alpha-alkylation of amides.
引用
收藏
页码：1144 / 1147
页数：4
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