Breakthrough invasive fungal diseases in acute myeloid leukemia patients receiving mould active triazole primary prophylaxis after intensive chemotherapy: An Italian consensus agreement on definitions and management

被引：20

作者：

Girmenia, Corrado ^{[1
]}

Busca, Alessandro ^{[2
]}

Candoni, Anna ^{[3
]}

Cesaro, Simone ^{[4
]}

Luppi, Mario ^{[5
]}

Nosari, Anna Maria ^{[6
,7
]}

Pagano, Livio ^{[8
]}

Rossi, Giuseppe ^{[9
,10
]}

Venditti, Adriano ^{[11
]}

Aversa, Franco ^{[12
]}

机构：

[1] Azienda Policlin Umberto I, Dipartimento Ematol Oncol & Dermatol, Via Benevento, I-00161 Rome, Italy

[2] AOU Citta Salute & Sci, Dipartimento Oncol, SSD Trapianto Allogen Cellule Staminali, Turin, Italy

[3] Azienda Osped Univ Udine, Ctr Trapianti & Terapie Cellulari, Clin Ematol, Udine, Italy

[4] Azienda Osped Univ Integrata, Oncoematol Pediat, Verona, Italy

[5] UNIMORE, AOU Modena, Cattedra & UO Ematol, Dipartimento Sci Med & Chirurg Materno Infantile, Modena, Italy

[6] ASST Grande Osped Metropolitano Niguarda, Div Ematol, Milan, Italy

[7] ASST Grande Osped Metropolitano Niguarda, Ctr Trapianti Midollo, Milan, Italy

[8] Univ Cattolica Sacro Cuore, IRCCS, Fdn Policlin A Gemelli, Div Ematol, Rome, Italy

[9] Spedali Civil Brescia, SC Ematol, Brescia, Italy

[10] Spedali Civil Brescia, Dipartimento Oncol Med, Brescia, Italy

[11] Fdn Policlin Tor Vergata, Ematol, Rome, Italy

[12] Univ Parma, Haematol & BMT Unit, Parma, Italy

来源：

MEDICAL MYCOLOGY | 2019年 / 57卷

关键词：

breakthrough fungal infections; antifungal prophylaxis; acute myeloid leukemia; triazoles; PRIMARY ANTIFUNGAL PROPHYLAXIS; ACUTE MYELOGENOUS LEUKEMIA; POSACONAZOLE PROPHYLAXIS; T-CELLS; CLINICAL EFFECTIVENESS; NEUTROPENIC PATIENTS; HEMATOLOGY PATIENTS; MYELODYSPLASTIC SYNDROMES; CYTOTOXIC CHEMOTHERAPY; INDUCTION CHEMOTHERAPY;

D O I：

10.1093/mmy/myy091

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In the attempt to establish definitions and provide shared approaches to breakthrough invasive fungal diseases (br-IFD) in acute myeloid leukemia (AML) patients submitted to intensive chemotherapy and receiving triazoles as mould active primary antifungal prophylaxis (MA-PAP), literature on br-IFD in AML patients receiving triazoles MA-PAP was reviewed and a Consensus Development Conference Project was convened. The following four candidate key-questions were generated and formed the set of questions of the present document: "definition of br-IFD," "diagnostic strategy during MA-PAP to detect br-IFD," "possible causes of MA-PAP failure," "management of br-IFD."

引用

页码：S127 / S137

页数：11

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