Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissues

被引：111

作者：

Ding, L

Erdmann, C

Chinnaiyan, AM

Merajver, SD

Kleer, CG

机构：

[1] Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Ctr Comprehens Canc, Sch Med, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 08期

关键词：

D O I：

10.1158/0008-5472.CAN-05-4300

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of molecular markers to detect the precancerous state would have profound implications in the prevention of breast cancer. We report that the expression of the Polycomb group protein EZH2 increases in histologically normal breast epithelium with higher risk of developing cancer. We identify EZH2 as a potential marker for detecting preneoplastic lesions of the breast in vivo and as a possible target for preventative intervention.

引用

收藏

页码：4095 / 4099

页数：5

相关论文

共 17 条

[1]

BACHMANN IM, 2005, J CLIN ONCOL, V24, P1

[2] EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer [J].

Adrian P. Bracken ;

Diego Pasini ;

Maria Capra ;

Elena Prosperini ;

Elena Colli ;

Kristian Helin .

The EMBO Journal, 2003, 22 (20) :5323-5335

[3] Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis [J].

Breuer, RHJ ;

Snijders, PJF ;

Smit, EF ;

Sutedja, TG ;

Sewalt, RGAB ;

Otte, AP ;

van Kemenade, FJ ;

Postmus, PE ;

Meijer, CJLM ;

Raaphorst, FM .

NEOPLASIA, 2004, 6 (06) :736-743

[4] Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancer [J].

Cavalli, LR ;

Singh, B ;

Isaacs, C ;

Dickson, RB ;

Haddad, BR .

CANCER GENETICS AND CYTOGENETICS, 2004, 149 (01) :38-43

[5] Histologically normal human mammary epithelia with silenced p16INK4a overexpress COX-2, promoting a premalignant program [J].

Crawford, YG ;

Gauthier, ML ;

Joubel, A ;

Mantei, K ;

Kozakiewicz, K ;

Afshari, CA ;

Tlsty, TD .

CANCER CELL, 2004, 5 (03) :263-273

[6] RISK-FACTORS FOR BREAST-CANCER IN WOMEN WITH PROLIFERATIVE BREAST DISEASE [J].

DUPONT, WD ;

PAGE, DL .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (03) :146-151

[7] p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue [J].

Gauthier, ML ;

Pickering, CR ;

Miller, CJ ;

Fordyce, CA ;

Chew, KL ;

Berman, HK ;

Tlsty, TD .

CANCER RESEARCH, 2005, 65 (05) :1792-1799

[8] Benign breast disease and the risk of breast cancer [J].

Hartmann, LC ;

Sellers, TA ;

Frost, MH ;

Lingle, WL ;

Degnim, AC ;

Ghosh, K ;

Vierkant, RA ;

Maloney, SD ;

Pankratz, VS ;

Hillman, DW ;

Suman, VJ ;

Johnson, J ;

Blake, C ;

Tlsty, T ;

Vachon, CM ;

Melton, LJ ;

Visscher, DW .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (03) :229-237

[9] Ki-67 expression in benign breast ductal cells obtained by random periareolar fine needle aspiration [J].

Khan, QJ ;

Kimler, BF ;

Clark, J ;

Metherty, T ;

Zalles, CM ;

Fabian, CJ .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (04) :786-789

[10] EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells [J].

Kleer, CG ;

Cao, Q ;

Varambally, S ;

Shen, RL ;

Ota, L ;

Tomlins, SA ;

Ghosh, D ;

Sewalt, RGAB ;

Otte, AP ;

Hayes, DF ;

Sabel, MS ;

Livant, D ;

Weiss, SJ ;

Rubin, MA ;

Chinnaiyan, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11606-11611