Capsaicin 8 % as a cutaneous patch (Qutenza™): analgesic effect on patients with peripheral neuropathic pain

被引:12
作者
Raber, Julia Marie [1 ]
Reichelt, Doris [2 ]
Grueneberg-Oelker, Ute [2 ]
Philipp, Konstanze [1 ]
Stubbe-Draeger, Bianca [3 ]
Husstedt, Ingo-W. [1 ]
机构
[1] Univ Hosp Munster, Dept Neurol, D-48149 Munster, Germany
[2] Univ Hosp Munster, Dept Gen Internal Med, D-48149 Munster, Germany
[3] Univ Hosp Munster, Dept Sleep Med & Neuromuscular Dis, D-48149 Munster, Germany
关键词
Capsaicin 8 % patch; Reduction of pain; Peripheral neuropathic pain; 8-PERCENT PATCH; MANAGEMENT;
D O I
10.1007/s13760-014-0395-7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Evaluation of the analgesic effect after a single application of the capsaicin 8 % cutaneous patch (Qutenza (TM)) in 37 patients suffering from painful, distal symmetric polyneuropathy (PNP) for an average of 5 years. Patients ranged from 40 to 78 years of age and 22 subjects were HIV-positive. Patients were observed 4 weeks prior to 12 weeks post administration. An evaluation of the therapeutic effect of capsaicin 8 % as a dermal patch in terms of pain reduction, change of sleeping behavior and social activities was performed and statistical analysis of data was conducted using non-parametric methods. Patients were selected according to clinical criteria. Numerical rating scale (NRS 0-10) was used to inquire pain intensity and a pain score was calculated using the painDETECT(A (c)) questionnaire Freynhagen R (Curr Med Res Opin 22:1911-1920, [2006]). A significant reduction of pain was achieved for up to 12 weeks, with a maximum after 2-4 weeks post administration. After patient education and before application of capsaicin patch, a significant reduction of three levels on the NRS was observed. Symptoms of painful PNP decreased over the period of investigation and 8 patients reported a reduction of systemic pain medication. In patients with an HIV infection, a significant extension of sleep was achieved for 2, 4 and 8 weeks after application. Thus, the application of the capsaicin 8 % patch resulted in a significant relief of neuropathic pain, a prolongation of sleep, a reduction of oral pain medication and a resumption of social activities.
引用
收藏
页码:335 / 343
页数:9
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