REM Sleep Behavior Disorder and Neuropathology in Parkinson's Disease

Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear. Methods: Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions. Results: Forty cases had probable RBD (PD1RBD), and 41 did not (PD-RBD). Despite similar age at death (similar to 80 y) and disease duration (similar to 14.5 y), PD1RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD1RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden was slightly higher in PD-RBD. Conclusions: Although overlap occurs between groups, PD patients with probable RBD may have greater density and range of synuclein pathology on autopsy. (c) 2015 International Parkinson and Movement Disorder Society