Transition-Metal-Mediated/Catalyzed Synthesis of Pyridines, Pyrimidines, and Triazines by [2+2+2] Cycloaddition Reactions

被引：48

作者：

Nagata, Tatsuki ^{[1
]}

Obora, Yasushi ^{[1
]}

机构：

[1] Kansai Univ, Dept Chem & Mat Engn, Suita, Osaka 5648680, Japan

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 9卷 / 10期

关键词：

Cycloaddition; Pyridine; Pyrimidine; Triazine; Nitrogen heterocycles; ONE-POT SYNTHESIS; IRON-CATALYZED CYCLOADDITION; 2 DIFFERENT ALKYNES; SUBSTITUTED PYRIDINES; CASCADE ANNULATION; PROMISING SCAFFOLD; NITRILES; DIYNES; DERIVATIVES; CYCLOTRIMERIZATION;

D O I：

10.1002/ajoc.202000240

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nitrogen-containing six-membered heterocycles such as pyridines, pyrimidines, and triazines are widely used in the synthesis of natural products and pharmaceuticals. Recently, a promising approach to these structures via [2+2+2] cycloadditions of alkynes and nitriles has been developed. Transition-metal complex catalysts play key roles in the regio-, chemo-, or stereo-selectivity of transformations. Here, we summarize recent advances in metal-mediated/catalyzed [2+2+2] cycloadditions for synthesizing pyridines and pyrimidines. We also describe progress in triazine synthesis via metal-mediated/catalyzed nitrile cyclotrimerization.

引用

页码：1532 / 1547

页数：16

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