There exists increasing evidence that apart from solid tumors, angiogenic growth factors also play important roles in the development and/or maintenance of hematolymphoid malignancies. Thus, in these cancers, angiogenesis and bone marrow microvessel density often correlate with prognosis and disease burden. Several reports speculated on the role of angiogenesis and the resulting possible therapeutic options in hematologic malignancies. The most prominent angiogenic factor, vascular endothelial growth factor (VEGF), is expressed in a number of established leukemic cell lines as well as in freshly isolated human leukemias and lymphomas, and several human leukemias express VEGF receptor 1 and/or VEGF receptor 2. VEGF/VEGF-receptor interactions are also involved in proliferation, migration, and survival of leukemic cells by autocrine and paracrine mechanisms. As a consequence, a possible drugable effect by inhibiting VEGF signaling in different hematologic malignancies has been discussed. This review focuses on angiogenesis-independent effects of VEGF on survival and proliferation of leukemic or lymphoma cells and on possible therapeutic approaches using anti-VEGF/VEGF-receptor therapies to inhibit proliferation or induce apoptosis of malignant cells in hematologic diseases.
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Imai, Norikazu
Miwa, Hiroshi
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Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Miwa, Hiroshi
Shikami, Masato
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Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Shikami, Masato
Suganuma, Kazuto
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机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Suganuma, Kazuto
Gotoh, Mayuko
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Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Gotoh, Mayuko
Hiramatsu, Akihito
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Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Hiramatsu, Akihito
Wakabayashi, Motohiro
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机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Wakabayashi, Motohiro
Watarai, Masaya
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机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Watarai, Masaya
Hanamura, Ichiro
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Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Hanamura, Ichiro
Imamura, Akira
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Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Imamura, Akira
Mihara, Hidetsugu
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机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Mihara, Hidetsugu
Shitara, Kenya
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机构:
Kyowa Hakko Kogyo Co Ltd, Antibody Business Off, Pharmaceut Business Unit, Tokyo, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Shitara, Kenya
Shibuya, Masabumi
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h-index: 0
机构:
Tokyo Med & Dent Univ, Dept Mol Oncol, Tokyo, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Shibuya, Masabumi
Nitta, Masakazu
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Imai, Norikazu
Miwa, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Miwa, Hiroshi
Shikami, Masato
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Shikami, Masato
Suganuma, Kazuto
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Suganuma, Kazuto
Gotoh, Mayuko
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Gotoh, Mayuko
Hiramatsu, Akihito
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Hiramatsu, Akihito
Wakabayashi, Motohiro
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Wakabayashi, Motohiro
Watarai, Masaya
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Watarai, Masaya
Hanamura, Ichiro
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Hanamura, Ichiro
Imamura, Akira
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Imamura, Akira
Mihara, Hidetsugu
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Mihara, Hidetsugu
Shitara, Kenya
论文数: 0引用数: 0
h-index: 0
机构:
Kyowa Hakko Kogyo Co Ltd, Antibody Business Off, Pharmaceut Business Unit, Tokyo, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Shitara, Kenya
Shibuya, Masabumi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Dept Mol Oncol, Tokyo, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan
Shibuya, Masabumi
Nitta, Masakazu
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, JapanAichi Med Univ, Dept Internal Med, Div Hematol, Sch Med, Aichi, Japan