Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review

被引：8
作者：
Pandiella-Alonso, Atanasio [1 ,2 ]
Diaz-Rodriguez, Elena [1 ,2 ]
Sanz, Eduardo [3 ]
机构：
[1] CSIC IBSAL, Inst Biol Mol & Celular Canc, Salamanca 37007, Spain
[2] CIBERONC, Salamanca 37007, Spain
[3] Catalysis SL, Madrid 28016, Spain
来源：
NUTRIENTS | 2020年 / 12卷 / 09期
关键词：
ocoxin; antitumoral; antioxidant; natural product; nutritional supplement; COLORECTAL-CANCER; (-)-EPIGALLOCATECHIN GALLATE; HEPATOCELLULAR-CARCINOMA; MACROPHAGE CYTOTOXICITY; GROWTH; APOPTOSIS; ARGININE; PROGRESSION; ACTIVATION; INHIBITION;
D O I：
10.3390/nu12092661
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as well as clinical trials is reviewed, paying special attention to the mechanism of action and quality of life improvement properties of this nutritional supplement. Molecularly, its mode of action includes a double edge role on tumor biology, that involves a slowdown in cell proliferation accompanied by cell death induction. Given the safety and good tolerability of OOS, and its potentiation of the antitumoral effect of other standard of care drugs, OOS may be used in the oncology clinic in combination with conventional therapies.
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页码：1 / 18
页数：18
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