Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as well as clinical trials is reviewed, paying special attention to the mechanism of action and quality of life improvement properties of this nutritional supplement. Molecularly, its mode of action includes a double edge role on tumor biology, that involves a slowdown in cell proliferation accompanied by cell death induction. Given the safety and good tolerability of OOS, and its potentiation of the antitumoral effect of other standard of care drugs, OOS may be used in the oncology clinic in combination with conventional therapies.
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Agathocleous, Michalis
;
Meacham, Corbin E.
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Meacham, Corbin E.
;
Burgess, Rebecca J.
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Burgess, Rebecca J.
;
Piskounova, Elena
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Piskounova, Elena
;
Zhao, Zhiyu
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机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Zhao, Zhiyu
;
Crane, Genevieve M.
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机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Crane, Genevieve M.
;
Cowin, Brianna L.
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Cowin, Brianna L.
;
Bruner, Emily
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Bruner, Emily
;
Murphy, Malea M.
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Murphy, Malea M.
;
Chen, Weina
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Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Chen, Weina
;
Spangrude, Gerald J.
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Univ Utah, Dept Med, Salt Lake City, UT 84112 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Spangrude, Gerald J.
;
Hu, Zeping
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Hu, Zeping
;
DeBerardinis, Ralph J.
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
DeBerardinis, Ralph J.
;
Morrison, Sean J.
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Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
机构:
Fred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Brasky, Theodore M.
;
Lampe, Johanna W.
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机构:
Fred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Lampe, Johanna W.
;
Slatore, Christopher G.
论文数: 0引用数: 0
h-index: 0
机构:
Portland VA Med Ctr, Portland, OR USA
Oregon Hlth & Sci Univ, Dept Pulm & Crit Care Med, Portland, OR 97201 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Slatore, Christopher G.
;
White, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Agathocleous, Michalis
;
Meacham, Corbin E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Meacham, Corbin E.
;
Burgess, Rebecca J.
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机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Burgess, Rebecca J.
;
Piskounova, Elena
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机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Piskounova, Elena
;
Zhao, Zhiyu
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h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Zhao, Zhiyu
;
Crane, Genevieve M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Crane, Genevieve M.
;
Cowin, Brianna L.
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h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Cowin, Brianna L.
;
Bruner, Emily
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h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Bruner, Emily
;
Murphy, Malea M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Murphy, Malea M.
;
Chen, Weina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Chen, Weina
;
Spangrude, Gerald J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Med, Salt Lake City, UT 84112 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Spangrude, Gerald J.
;
Hu, Zeping
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Hu, Zeping
;
DeBerardinis, Ralph J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
DeBerardinis, Ralph J.
;
Morrison, Sean J.
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h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA
Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USAUniv Texas Southwestern Med Ctr Dallas, Childrens Res Inst, Dallas, TX 75390 USA
机构:
Fred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Brasky, Theodore M.
;
Lampe, Johanna W.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Lampe, Johanna W.
;
Slatore, Christopher G.
论文数: 0引用数: 0
h-index: 0
机构:
Portland VA Med Ctr, Portland, OR USA
Oregon Hlth & Sci Univ, Dept Pulm & Crit Care Med, Portland, OR 97201 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Slatore, Christopher G.
;
White, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Canc Prevent Unit, Seattle, WA 98109 USA