Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?

被引：122

作者：

Webster, Joanne P. ^{[1
]}

Kaushik, Maya ^{[1
]}

Bristow, Greg C. ^{[2
]}

McConkey, Glenn A. ^{[2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, Dept Infect Dis Epidemiol, London W2 1PG, England

[2] Univ Leeds, Sch Biol, Fac Biol Sci, Leeds LS2 9JT, W Yorkshire, England

来源：

JOURNAL OF EXPERIMENTAL BIOLOGY | 2013年 / 216卷 / 01期

基金：

英国医学研究理事会;

关键词：

Toxoplasma gondii; rat; mouse; behaviour; manipulation; by-product; pathology; schizophrenia; intermediate host; secondary host; 3Rs; CARD SORTING TEST; ELEVATED PLUS-MAZE; NMDA RECEPTOR HYPOFUNCTION; DOPAMINE HYPOTHESIS; ALTERED BEHAVIOR; NOVELTY DISCRIMINATION; COGNITIVE NEUROSCIENCE; SCHISTOSOMA-MANSONI; OBJECT RECOGNITION; TRAFFIC ACCIDENTS;

D O I：

10.1242/jeb.074716

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We examine the role of the protozoan Toxoplasma gondii as a manipulatory parasite and question what role study of infections in its natural intermediate rodent hosts and other secondary hosts, including humans, may elucidate in terms of the epidemiology, evolution and clinical applications of infection. In particular, we focus on the potential association between T. gondii and schizophrenia. We introduce the novel term 'T. gondii-rat manipulation-schizophrenia model' and propose how future behavioural research on this model should be performed from a biological, clinical and ethically appropriate perspective.

引用

页码：99 / 112

页数：14

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