miRNAs and related polymorphisms in rheumatoid arthritis susceptibility

被引：77

作者：

Chatzikyriakidou, Anthoula ^{[2
]}

Voulgari, Paraskevi V. ^{[1
]}

Georgiou, Ioannis ^{[2
]}

Drosos, Alexandros A. ^{[1
]}

机构：

[1] Univ Ioannina, Sch Med, Dept Internal Med, Rheumatol Clin, GR-45110 Ioannina, Greece

[2] Univ Ioannina, Sch Med, Genet Unit, Dept Obstet & Gynecol, GR-45110 Ioannina, Greece

来源：

AUTOIMMUNITY REVIEWS | 2012年 / 11卷 / 09期

关键词：

Rheumatoid arthritis; microRNA; Single nucleotide polymorphism; SINGLE-NUCLEOTIDE POLYMORPHISMS; GASTRIC-CANCER RISK; FUNCTIONAL POLYMORPHISM; SYNOVIAL FIBROBLASTS; MIR-146A EXPRESSION; ALTERED EXPRESSION; INNATE IMMUNITY; MESSENGER-RNAS; PRE-MICRORNAS; BINDING-SITES;

D O I：

10.1016/j.autrev.2011.11.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The epigenetic mechanisms in regulation of genes' expression seem to be another field of research that gains land in genetic association studies of rheumatoid arthritis (RA) susceptibility factors. Recently, a new class of molecules has been discovered, the microRNAs (miRNAs). miRNAs are related to post-transcriptional regulation of genes' expression. Different expression patterns of mir-146a, miRNA-155, miRNA-124a, mir-203, mir-223, mir-346, mir-132, mir-363, mir-498, mir-15a, and mir-16 were documented in several tissue sample types of RA patients. The polymorphisms of these miRNAs and their gene targets, which previously have been associated with RA or other autoimmune diseases, are also reviewed. Finally, using web-based tools we propose polymorphisms of the discussed miRNAs and their gene-targets that worth to be studied for their role in RA predisposition. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：636 / 641

页数：6

共 78 条

[1] Epidemiology of adult rheumatoid arthritis [J].

Alamanos, Y ;

Drosos, AA .

AUTOIMMUNITY REVIEWS, 2005, 4 (03) :130-136

[2] Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: A systematic review [J].

Alamanos, Yannis ;

Voulgari, Paraskevi V. ;

Drosos, Alexandros A. .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2006, 36 (03) :182-188

[3] MicroRNAs in Sjogren's syndrome as a prototypic autoimmune disease [J].

Alevizos, Ilias ;

Illei, Gabor G. .

AUTOIMMUNITY REVIEWS, 2010, 9 (09) :618-621

[4] Bruton's Tyrosine Kinase Is Involved in miR-346-Related Regulation of IL-18 Release by Lipopolysaccharide-Activated Rheumatoid Fibroblast-Like Synoviocytes [J].

Alsaleh, Ghada ;

Suffert, Guillaume ;

Semaan, Noha ;

Juncker, Tom ;

Frenzel, Laurent ;

Gottenberg, Jacques-Eric ;

Sibilia, Jean ;

Pfeffer, Sebastien ;

Wachsmann, Dominique .

JOURNAL OF IMMUNOLOGY, 2009, 182 (08) :5088-5097

[5] MicroRNA-15a fine-tunes the level of Delta-like 1 homolog (DLK1) in proliferating 3T3-L1 preadipocytes [J].

Andersen, Ditte C. ;

Jensen, Charlotte H. ;

Schneider, Mikael ;

Nossent, Anne Yael ;

Eskildsen, Tilde ;

Hansen, Jakob L. ;

Teisner, Borge ;

Sheikh, Soren P. .

EXPERIMENTAL CELL RESEARCH, 2010, 316 (10) :1681-1691

[6] MicroSNiPer: A Web Tool for Prediction of SNP Effects on Putative microRNA Targets [J].

Barenboim, Maxim ;

Zoltick, Brad J. ;

Guo, Yongjian ;

Weinberger, Daniel R. .

HUMAN MUTATION, 2010, 31 (11) :1223-1232

[7] Genetic Susceptibility to Rheumatoid Arthritis: An Emerging Picture [J].

Barton, Anne ;

Worthington, Jane .

ARTHRITIS CARE & RESEARCH, 2009, 61 (10) :1441-1446

[8] Gene Expression and Single Nucleotide Polymorphism Array Analyses of Spindle Cell Lipomas and Conventional Lipomas with 13q14 Deletion [J].

Bartuma, Hammurabi ;

Nord, Karolin H. ;

Macchia, Gemma ;

Isaksson, Margareth ;

Nilsson, Jenny ;

Domanski, Henryk A. ;

Mandahl, Nils ;

Mertens, Fredrik .

GENES CHROMOSOMES & CANCER, 2011, 50 (08) :619-632

[9] MiR-15a and MiR-16 Control Bmi-1 Expression in Ovarian Cancer [J].

Bhattacharya, Resham ;

Nicoloso, Milena ;

Arvizo, Rochelle ;

Wang, Enfeng ;

Cortez, Angelica ;

Rossi, Simona ;

Calin, George A. ;

Mukherjee, Priyabrata .

CANCER RESEARCH, 2009, 69 (23) :9090-9095

[10] Methylation-induced repression - Belts, braces, and chromatin [J].

Bird, AP ;

Wolffe, AP .

CELL, 1999, 99 (05) :451-454

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