Effect of oxygen therapy on myocardial salvage in ST elevation myocardial infarction: the randomized SOCCER trial

ObjectiveRecent studies suggest that administration of O-2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O-2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI).Materials and methodsThis study was a randomized-controlled trial conducted at two university hospitals in Sweden. Normoxic STEMI patients were randomized in the ambulance to either supplemental O-2 (10l/min) or room air until the conclusion of the PCI. CMR was performed 2-6 days after the inclusion. The primary endpoint was the myocardial salvage index assessed by CMR. The secondary endpoints included infarct size and myocardium at risk.ResultsAt inclusion, the O-2 (n=46) and air (n=49) patient groups had similar patient characteristics. There were no significant differences in myocardial salvage index [53.925.1 vs. 49.3 +/- 24.0%; 95% confidence interval (CI): -5.4 to 14.6], myocardium at risk (31.9 +/- 10.0% of the left ventricle in the O-2 group vs. 30.0 +/- 11.8% in the air group; 95% CI: -2.6 to 6.3), or infarct size (15.6 +/- 10.4% of the left ventricle vs. 16.0 +/- 11.0%; 95% CI: -4.7 to 4.1).ConclusionIn STEMI patients undergoing acute PCI, we found no effect of high-flow oxygen compared with room air on the size of ischemia before PCI, myocardial salvage, or the resulting infarct size. These results support the safety of withholding supplemental oxygen in normoxic STEMI patients.