Soluble polyelectrolyte complexes of biopolymers

被引：17

作者：

Izumrudov, V. A. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119991, Russia

来源：

POLYMER SCIENCE SERIES A | 2012年 / 54卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

WATER-SALT SOLUTIONS; PLASMID DNA; POLYPYRIDYLPHENYLENE DENDRIMERS; INTERPOLYELECTROLYTE COMPLEXES; STARBURST DENDRIMERS; PHASE SEPARATIONS; GENETIC MATERIAL; DELIVERY; CHITOSAN; POLYCATIONS;

D O I：

10.1134/S0965545X12010117

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This review analyzes the papers reflecting the state of the art and achievements in the field of experimental investigations of solutions of polyelectrolyte complexes containing biopolymers, specifically oligomeric enzymes, cationic polysaccharide chitosan, or DNA. The analysis shows that the use of soluble complexes is promising for solving urgent practical problems. The development of methods for suppressing thermal aggregation of globular proteins without any substantial loss in functional activity, for imparting chitosan the ability to dissolve under physiological conditions and to form polyelectrolyte complexes, and for creating dual-action dendrimer carriers that can simultaneously deliver genetic material and drugs to cells are among the most significant directions.

引用

页码：513 / 520

页数：8

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