Emerging role of autophagy in kidney function, diseases and aging

被引：237
作者：
Huber, Tobias B. [1 ,2 ]
Edelstein, Charles L. [3 ]
Hartleben, Bjoern [1 ]
Inoki, Ken [4 ,5 ,6 ]
Jiang, Man [7 ,8 ]
Koya, Daisuke [9 ]
Kume, Shinji [10 ]
Lieberthal, Wilfred [11 ]
Pallet, Nicolas [12 ]
Quiroga, Alejandro [13 ]
Ravichandran, Kameswaran [3 ]
Susztak, Katalin [13 ]
Yoshida, Sei [4 ]
Dong, Zheng [7 ,8 ]
机构：
[1] Univ Hosp Freiburg, Div Renal, Freiburg, Germany
[2] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany
[3] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO USA
[4] Univ Michigan, Sch Med, Inst Life Sci, Ann Arbor, MI USA
[5] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI USA
[6] Univ Michigan, Sch Med, Dept Internal Med, Div Nephrol, Ann Arbor, MI USA
[7] Georgia Hlth Sci Univ, Dept Cellular Biol & Anat, Augusta, GA USA
[8] Charlie Norwood VA Med Ctr, Augusta, GA USA
[9] Kanazawa Med Univ, Div Diabet & Endocrinol, Kanazawa, Ishikawa, Japan
[10] Shiga Univ Med Sci, Dept Med, Otsu, Shiga 52021, Japan
[11] Stony Brook Univ Hosp, Dept Med, Stony Brook, NY USA
[12] Univ Paris 05, Hop Necker, Serv Transplantat Renale & Soins Intensifs, Paris, France
[13] Albert Einstein Coll Med, Bronx, NY 10467 USA
来源：
AUTOPHAGY | 2012年 / 8卷 / 07期
基金：
美国国家卫生研究院;
关键词：
autophagy; kidney; acute kidney injury; aging; polycystic kidney disease; podocyte; glomerulus; kidney transplantation; mTOR; CHAPERONE-MEDIATED AUTOPHAGY; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; ACUTE-RENAL-FAILURE; TUBEROUS SCLEROSIS COMPLEX; TUBULAR EPITHELIAL-CELLS; LIFE-SPAN EXTENSION; DIABETIC-NEPHROPATHY; MAMMALIAN TARGET; CALORIE RESTRICTION;
D O I：
10.4161/auto.19821
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.
引用
收藏
页码：1009 / 1031
页数：23
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