Emerging role of autophagy in kidney function, diseases and aging

被引：237

作者：

Huber, Tobias B. ^{[1
,2
]}

Edelstein, Charles L. ^{[3
]}

Hartleben, Bjoern ^{[1
]}

Inoki, Ken ^{[4
,5
,6
]}

Jiang, Man ^{[7
,8
]}

Koya, Daisuke ^{[9
]}

Kume, Shinji ^{[10
]}

Lieberthal, Wilfred ^{[11
]}

Pallet, Nicolas ^{[12
]}

Quiroga, Alejandro ^{[13
]}

Ravichandran, Kameswaran ^{[3
]}

Susztak, Katalin ^{[13
]}

Yoshida, Sei ^{[4
]}

Dong, Zheng ^{[7
,8
]}

机构：

[1] Univ Hosp Freiburg, Div Renal, Freiburg, Germany

[2] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany

[3] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO USA

[4] Univ Michigan, Sch Med, Inst Life Sci, Ann Arbor, MI USA

[5] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI USA

[6] Univ Michigan, Sch Med, Dept Internal Med, Div Nephrol, Ann Arbor, MI USA

[7] Georgia Hlth Sci Univ, Dept Cellular Biol & Anat, Augusta, GA USA

[8] Charlie Norwood VA Med Ctr, Augusta, GA USA

[9] Kanazawa Med Univ, Div Diabet & Endocrinol, Kanazawa, Ishikawa, Japan

[10] Shiga Univ Med Sci, Dept Med, Otsu, Shiga 52021, Japan

[11] Stony Brook Univ Hosp, Dept Med, Stony Brook, NY USA

[12] Univ Paris 05, Hop Necker, Serv Transplantat Renale & Soins Intensifs, Paris, France

[13] Albert Einstein Coll Med, Bronx, NY 10467 USA

来源：

AUTOPHAGY | 2012年 / 8卷 / 07期

基金：

美国国家卫生研究院;

关键词：

autophagy; kidney; acute kidney injury; aging; polycystic kidney disease; podocyte; glomerulus; kidney transplantation; mTOR; CHAPERONE-MEDIATED AUTOPHAGY; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; ACUTE-RENAL-FAILURE; TUBEROUS SCLEROSIS COMPLEX; TUBULAR EPITHELIAL-CELLS; LIFE-SPAN EXTENSION; DIABETIC-NEPHROPATHY; MAMMALIAN TARGET; CALORIE RESTRICTION;

D O I：

10.4161/auto.19821

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.

引用

页码：1009 / 1031

页数：23

共 50 条

[31] Autophagy and kidney aging
Minami, Satoshi
Yamamoto, Takeshi
Yamamoto-Imoto, Hitomi
Isaka, Yoshitaka
Hamasaki, Maho
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2023, 179 : 10 - 15
[32] The Multiple Roles of Autophagy in Neural Function and Diseases
Yan-Yan Li
Zheng-Hong Qin
Rui Sheng
Neuroscience Bulletin, 2024, 40 : 363 - 382
[33] Editorial: Autophagy in Endocrine-Metabolic Diseases Associated With Aging
Vaccaro, Maria Ines
De Tata, Vincenzo
Gonzalez, Claudio Daniel
FRONTIERS IN ENDOCRINOLOGY, 2020, 11
[34] Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential
Yang, Danyi
Livingston, Man J.
Liu, Zhiwen
Dong, Guie
Zhang, Ming
Chen, Jian-Kang
Dong, Zheng
CELLULAR AND MOLECULAR LIFE SCIENCES, 2018, 75 (04) : 669 - 688
[35] Autophagy and Inflammation Regulation in Acute Kidney Injury
Gong, Li
Pan, Qinjun
Yang, Nianlan
FRONTIERS IN PHYSIOLOGY, 2020, 11
[36] Regulation of Autophagy by TGF-β: Emerging Role in Kidney Fibrosis
Ding, Yan
Choi, Maly E.
SEMINARS IN NEPHROLOGY, 2014, 34 (01) : 62 - 71
[37] Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases
Ren, Jun
Zhang, Yingmei
TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 39 (12) : 1064 - 1076
[38] Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy
Knuppertz, Laura
Osiewacz, Heinz D.
MECHANISMS OF AGEING AND DEVELOPMENT, 2016, 153 : 30 - 40
[39] Emerging role of aging in the progression of NAFLD to HCC
He, Yongyuan
Su, Yinghong
Duan, Chengcheng
Wang, Siyuan
He, Wei
Zhang, Yingting
An, Xiaofei
He, Ming
AGEING RESEARCH REVIEWS, 2023, 84
[40] Aging: Central role for autophagy and the lysosomal degradative system
Rajawat, Yogendra S.
Hilioti, Zoe
Bossis, Ioannis
AGEING RESEARCH REVIEWS, 2009, 8 (03) : 199 - 213

← 1 2 3 4 5 →