Ictal high-gamma oscillation (60-99 Hz) in intracranial electroencephalography and postoperative seizure outcome in neocortical epilepsy

被引：32

作者：

Park, Seong-Cheol ^{[1
]}

Lee, Sang Kun ^{[2
]}

Che, Huije ^{[3
]}

Chung, Chun Kee ^{[1
,3
,4
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Neurosurg, Seoul 110744, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Neurol, Seoul 110744, South Korea

[3] Seoul Natl Univ Hosp, Magnetoencephalog Ctr, Seoul 110744, South Korea

[4] Seoul Natl Univ, Med Res Ctr, Neurosci Res Inst, Seoul 110744, South Korea

来源：

CLINICAL NEUROPHYSIOLOGY | 2012年 / 123卷 / 06期

关键词：

Intracranial electroencephalography; Epileptogenicity index; High-gamma oscillation; Neocortical epilepsy; Seizure outcome; HIGH-FREQUENCY OSCILLATIONS; TEMPORAL-LOBE EPILEPSY; ENTORHINAL CORTEX; INTERICTAL SPIKES; INTRACEREBRAL EEG; ONSET PATTERNS; IN-VITRO; NETWORKS; CLASSIFICATION; HIPPOCAMPUS;

D O I：

10.1016/j.clinph.2012.01.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: High-gamma oscillations (HGOs) (60-99 Hz) have been suggested to correlate with seizure onset zones and seizure outcomes. We investigated the correlation between the extent of removal of ictal HGO generating areas and postoperative seizure outcome in neocortical epilepsy (NE). Methods: Twenty three patients with medically intractable NE underwent chronic intracranial electroencephalography (iEEG) using subdural electrodes. Ictal HGOs and superimposed undersampled ripples within +/- 3 s of video-iEEG ictal onset were extracted by wavelet clustering and thresholding. Cluster epileptogenicity indices (CEIs) were calculated. The temporal analysis window was locked to the timing of the maximum CEI wavecluster. Root mean square amplitudes, cross-correlation synchronies and the local focus indices within the temporal window were calculated. Results: Percentages of resected maximum CEI waveclusters and HGO zones with high standardised amplitudes (>3), high cross-correlation synchronies (>0.9) and high local focus indices (>2) were significantly higher in the seizure-free group compared to the not seizure-free group (p = 0.036, p = 0.018, and p = 0.026, respectively). Conclusions: The automatic quantitative ictal HGO analysis may be effective in delineating the epileptogenic zone. Significance: HGO analysis may be helpful for improving post-resection seizure outcome in NE in the future. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：1100 / 1110

页数：11