Co-administration of caffeine and caffeic acid alters some key enzymes linked with reproductive function in male rats

被引：19

作者：

Akomolafe, S. F. ^{[1
]}

Akinyemi, A. J. ^{[2
]}

Oboh, G. ^{[3
]}

Oyeleye, S. I. ^{[3
,4
]}

Ajayi, O. B. ^{[1
]}

Omonisi, A. E. ^{[5
]}

Owolabi, F. L. ^{[1
]}

Atoyebi, D. A. ^{[1
]}

Ige, F. O. ^{[1
]}

Atoki, V. A. ^{[1
]}

机构：

[1] Ekiti State Univ, Dept Biochem, Ado Ekiti, Nigeria

[2] Afe Babalola Univ, Dept Biochem, Ado Ekiti, Nigeria

[3] Fed Univ Technol Akure, Funct Foods & Nutraceut Unit, Dept Biochem, Akure, Nigeria

[4] Fed Univ Technol Akure, Dept Biomed Technol, Akure, Nigeria

[5] Ekiti State Univ, Dept Anat Pathol, Ado Ekiti, Nigeria

来源：

ANDROLOGIA | 2018年 / 50卷 / 02期

关键词：

caffeic acid; caffeine; fertility; hormones; steroidogenic enzymes; NITRIC-OXIDE SYNTHASE; SEMINAL PLASMA; SEMEN QUALITY; ZINC; CELL; SUPPLEMENTATION; TESTOSTERONE; INFERTILITY; POPULATION;

D O I：

10.1111/and.12839

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

This study assessed the effects of caffeine combined with caffeic acid on some biomarkers of male reproductive function using normal albino Wistar rats. Rats were divided into four groups (n=6) and treated for seven successive days; group 1 represents the control rats; group 2 rats were treated with 50mg/kg body weight (BW) of caffeine only; group 3 rats were treated with 50mg/kg BW of caffeic acid, while the rats in group 4 were cotreated with an equal combination of caffeine and caffeic acid. The results revealed significant increase in reproductive hormone, testicular and epididymal nitric oxide levels of the rats. Moreover, decreased oxidative stress in the testes and epididymides of the treated rats was evidenced by significant increase in total and nonprotein thiol levels, catalase and superoxide dismutase activities. Similarly, decreased testicular cholesterol level with concomitant elevation in testicular steroidogenic enzyme activities, glycogen and zinc levels were observed in the treated rats. No morphological changes were observed as revealed by the photomicrographs from light microscopy in treated rats. Nevertheless, the combination therapy exhibited additive/synergistic effect on these biochemical indices than when they were administered singly. This study suggests the combination therapy of caffeine and caffeic acid at the dose tested for improving male reproductive function.

引用

页数：10

共 53 条

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