Identification of nitrated proteins in the normal rat brain using a proteomics approach

被引：10
作者：
Suzuki, Y
Tanaka, M
Sohmiya, M
Ichinose, S
Omori, A
Okamoto, K
机构：
[1] Gunma Univ, Grad Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan
[2] MITILS, Machida, Tokyo 1948511, Japan
来源：
NEUROLOGICAL RESEARCH | 2005年 / 27卷 / 06期
关键词：
clathrin heavy chain; nitrated protein; proteomics; rat brain; T-complex polypeptide 1 alpha subunit;
D O I：
10.1179/016164105X22039
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The nitration of tyrosine has been suggested to play a role in the pathogenesis of neuroclegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD). Methods: In the present study, we identified four targets of protein nitration, T-complex polypepticle 1 alpha subunit (TCP-1), neurofilament L (NFL), glial fibrillary acidic protein (GFAP) and clathrin heavy chain (CHC), in the normal rat cortex using a proteomics approach. Conclusions: There have been no reports on these proteins being identified by proteomics as nitrated forms in the brain. For further study, we have to investigate alterations in these nitrated proteins during aging and in neurodegenerative disorders.
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收藏
页码：630 / 633
页数：4
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