Hydroalkylation of Olefins To Form Quaternary Carbons

被引：147

作者：

Green, Samantha A. ^{[1
]}

Huffman, Tucker R. ^{[1
]}

McCourt, Ruairi O. ^{[1
]}

van der Puyl, Vincent ^{[1
]}

Shenvi, Ryan A. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 19期

基金：

美国国家科学基金会;

关键词：

TERTIARY ALKYL-HALIDES; PHENYLSILANE; MN; FE;

D O I：

10.1021/jacs.9b02844

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to pi-radical traps; no sp(3) electrophiles have been reported. Here we describe a Mn/Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary carbons.

引用

页码：7709 / 7714

页数：6

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