Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosis

被引：19

作者：

Ayesa-Arriola, Rosa ^{[1
,2
]}

Perez-Iglesias, Rocio ^{[1
,2
,3
]}

Manuel Rodriguez-Sanchez, Jose ^{[1
,2
]}

Pardo-Garcia, Gema ^{[1
]}

Tabares-Seisdedos, Rafael ^{[2
,4
]}

Ayuso-Mateos, Jose L. ^{[2
,5
]}

Vazquez-Barquero, Jose L. ^{[1
,2
]}

Crespo-Facorro, Benedicto ^{[1
,2
]}

机构：

[1] Univ Cantabria, Marques de Valdecilla Univ Hosp, Sch Med, IFIMAV,Dept Psychiat, E-39005 Santander, Spain

[2] Ctr Invest Biomed Red Salud Mental, CIBERSAM, Madrid, Spain

[3] Inst Psychiat, Psychosis Studies Dept, London, England

[4] Univ Valencia, Dept Med, Valencia, Spain

[5] Univ Autonoma Madrid, Dept Psychiat, Madrid, Spain

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2013年 / 43卷

关键词：

First episode psychosis; Neurocognition; Schizophrenia; DSM-V CRITERIA; COGNITIVE IMPAIRMENT; SCHIZOPHRENIA-PATIENTS; NEUROPSYCHOLOGICAL DEFICITS; 1ST-EPISODE SCHIZOPHRENIA; LIFE SKILLS; METAANALYSIS; MOTOR; RISK; HALOPERIDOL;

D O I：

10.1016/j.pnpbp.2012.11.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Neurocognitive impairment is a core component of schizophrenia. However, patients show great variability in the level and course of deficits. The goal of the present longitudinal study was to identify predictors of neurocognitive impairment in first episode psychosis patients. Methods: Neurocognitive performance was analyzed in a cohort of 146 patients 3 years after a first episode non-affective psychosis. Subgroups, impaired vs. unimpaired, were compared on baseline clinical, neuropsychological, premorbid and sociodemographic characteristics. Results: Fifty-nine percent of participants presented general neurocognitive impairment and regression analyses demonstrated that clinical and sociodemographic characteristics were not predictive variables. A model composed of premorbid IQ, verbal memory and motor dexterity correctly classified 79.6% of the individuals. Conclusions: The present study gives information on frequency and neurocognitive profile of subtypes of patients showing impairment. Our results suggest general neurocognitive impairment is a trait dimension of the disorder related to specific cognitive dysfunctions. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：23 / 28

页数：6

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[1] RELIABILITY AND VALIDITY OF A DEPRESSION RATING-SCALE FOR SCHIZOPHRENICS [J].