Effects of working memory training on functional connectivity and cerebral blood flow during rest

被引:134
作者
Takeuchi, Hikaru [1 ]
Taki, Yasuyuki [2 ]
Nouchi, Rui [1 ]
Hashizume, Hiroshi [2 ]
Sekiguchi, Atsushi [3 ]
Kotozaki, Yuka [1 ]
Nakagawa, Seishu [3 ]
Miyauchi, Calros M. [3 ]
Sassa, Yuko [2 ]
Kawashima, Ryuta [1 ,2 ,3 ]
机构
[1] Tohoku Univ, IDAC, Smart Ageing Int Res Ctr, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, IDAC, Div Dev Cognit Neurosci, Sendai, Miyagi 9808575, Japan
[3] Tohoku Univ, IDAC, Dept Funct Brain Imaging, Sendai, Miyagi 9808575, Japan
关键词
Working memory training; Functional connectivity; Cerebral blood flow; Rest; Plasticity; COGNITIVE FUNCTIONS; DEFAULT NETWORK; STATE NETWORKS; BRAIN; ATTENTION; SCHIZOPHRENIA; DYSFUNCTION; CHILDREN; HYPERACTIVITY; INTELLIGENCE;
D O I
10.1016/j.cortex.2012.09.007
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Working memory (WM) training (WMT) alters the task-related brain activity and structure of the external attention system (EAS). We investigated whether WMT also alters resting-state brain mechanisms, which are assumed to reflect intrinsic brain activity and connectivity. Our study subjects were subjected to a 4-week WMT program and brain scans before and after the intervention for determining changes of functional connectivity and regional cerebral blood flow during rest (resting-FC/resting-rCBF). Compared with no-intervention, WMT (a) increased resting-FC between the medial prefrontal cortex (mPFC) and precuneus, which are key nodes of the default mode network (DMN), (b) decreased resting-PC between mPFC and the right posterior parietal cortex/right lateral prefrontal cortex (LPFC), which are key nodes of the EAS, and (c) increased resting-rCBF in the right LPFC. However, the training-related decreases in resting-PC between the key DMN node. and the nodes of EAS were only observed when the whole brain signal was regressed out in individual analyses, and these changes were not observed when the whole brain signal was not regressed out in individual analyses. Further analyses indicated that these differences may be mediated by a weak but a widespread increase in resting-PC between the nodes of EAS and activity of multiple bilateral areas across the brain. These results showed that WMT induces plasticity in neural mechanisms involving DMN and the EAS during rest and indicated that intrinsic brain activity and connectivity can be affected by cognitive training. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2106 / 2125
页数:20
相关论文
共 91 条
[1]   The Resting Human Brain and Motor Learning [J].
Albert, Neil B. ;
Robertson, Edwin M. ;
Miall, R. Chris .
CURRENT BIOLOGY, 2009, 19 (12) :1023-1027
[2]  
[Anonymous], 2003, MANUAL NEW TANAKA B
[3]   Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[4]   Working memory: Looking back and looking forward [J].
Baddeley, A .
NATURE REVIEWS NEUROSCIENCE, 2003, 4 (10) :829-839
[5]   Social disengagement and incident cognitive decline in community-dwelling elderly persons [J].
Bassuk, SS ;
Glass, TA ;
Berkman, LF .
ANNALS OF INTERNAL MEDICINE, 1999, 131 (03) :165-+
[6]   INDIVIDUAL-DIFFERENCES IN NEGATIVE PRIMING - RELATIONS WITH SCHIZOTYPAL PERSONALITY-TRAITS [J].
BEECH, A ;
CLARIDGE, G .
BRITISH JOURNAL OF PSYCHOLOGY, 1987, 78 :349-356
[7]   METABOLIC ANATOMY OF BRAIN - A COMPARISON OF REGIONAL CAPILLARY DENSITY, GLUCOSE-METABOLISM, AND ENZYME-ACTIVITIES [J].
BOROWSKY, IW ;
COLLINS, RC .
JOURNAL OF COMPARATIVE NEUROLOGY, 1989, 288 (03) :401-413
[8]   Default-mode brain dysfunction in mental disorders: A systematic review [J].
Broyd, Samantha J. ;
Demanuele, Charmaine ;
Debener, Stefan ;
Helps, Suzannah K. ;
James, Christopher J. ;
Sonuga-Barke, Edmund J. S. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2009, 33 (03) :279-296
[9]   The brain's default network - Anatomy, function, and relevance to disease [J].
Buckner, Randy L. ;
Andrews-Hanna, Jessica R. ;
Schacter, Daniel L. .
YEAR IN COGNITIVE NEUROSCIENCE 2008, 2008, 1124 :1-38
[10]   Biological parametric mapping: A statistical toolbox for multimodality brain image analysis [J].
Casanova, Ramon ;
Srikanth, Ryali ;
Baer, Aaron ;
Laurienti, Paul J. ;
Burdett, Jonathan H. ;
Hayasaka, Satoru ;
Flowers, Lynn ;
Wood, Frank ;
Maldjian, Joseph A. .
NEUROIMAGE, 2007, 34 (01) :137-143