Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy

被引：57
作者：
Stehle, Thomas [1 ]
Audard, Vincent [2 ,3 ]
Ronco, Pierre [4 ]
Debiec, Hanna [4 ]
机构：
[1] Hop Necker Enfants Malad, AP HP, Serv Nephrol & Dialyse, Paris, France
[2] UPEC, Hop Henri Mondor, AP HP, Serv Nephrol & Transplantat,IFRNT, Creteil, France
[3] UPEC, INSERM, U955, Equipe 21,Ctr Reference Syndrome Nephrot Idiopath, Creteil, France
[4] UPMC, Tenon Hosp, APHP, INSERM,Unit UMR S1155, Paris, France
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2015年 / 30卷 / 06期
关键词：
membranous nephropathy; phospholipase A2 receptor; sarcoidosis; AUTOANTIBODIES; ANTIBODIES;
D O I：
10.1093/ndt/gfv080
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis. Our results suggest some causal link between sarcoidosis and PLA2R-related MN. Detection of anti-PLA2R antibodies in serum or PLA2R antigen in biopsy should not be taken as evidence against a secondary cause, particularly sarcoidosis. This important observation can affect treatment decision in these patients.
引用
收藏
页码：1047 / 1050
页数：4
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