High Endothelial Venule with Concomitant High CD8+Tumor-Infiltrating Lymphocytes Is Associated with a Favorable Prognosis in Resected Gastric Cancer

被引：26

作者：

Hong, Soon Auck ^{[1
]}

Hwang, Hye Won ^{[1
]}

Kim, Min Kyoon ^{[2
]}

Lee, Tae Jin ^{[1
]}

Yim, Kwangil ^{[3
]}

Won, Hye Sung ^{[4
]}

Sun, Der Sheng ^{[4
]}

Kim, Eun Young ^{[5
]}

Ko, Yoon Ho ^{[4
,6
]}

机构：

[1] Chung Ang Univ, Dept Pathol, Coll Med, Seoul 06974, South Korea

[2] Chung Ang Univ, Coll Med, Chung Ang Univ Hosp, Dept Surg, Seoul 06974, South Korea

[3] Catholic Univ Korea, Dept Hosp Pathol, Uijeongbu St Marys Hosp, Coll Med, Seoul 06591, South Korea

[4] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Med Oncol, Seoul 06591, South Korea

[5] Catholic Univ Korea, Coll Med, Dept Surg, Uijeongbu St Marys Hosp, Seoul 06591, South Korea

[6] Catholic Univ Korea, Coll Med, Canc Res Inst, Seoul 06591, South Korea

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

gastric cancer; high endothelial venule; CD8+tumor-infiltrating lymphocytes; prognosis; REGULATORY T-CELLS; SOLID TUMORS; INFILTRATION; VESSELS; FOXP3; RECRUITMENT; MEMORY; HEVS;

D O I：

10.3390/jcm9082628

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CD8+ tumor-infiltrating lymphocytes (TILs) play a major role in antitumor immunity. High endothelial venules (HEVs) are related to diverse immune cells in solid tumors. We analyzed CD8+ and Foxp3+ TILs in combination with HEVs to determine their prognostic role in advanced gastric cancer (AGC). We enrolled 157 patients with AGC in this study. The densities of CD8+ TILs and Foxp3+ TILs were calculated using immunohistochemical staining. HEVs were evaluated by MECA-79 expression. HEVs were identified in 60 (38.2%) cases and was significantly associated with an increased number of CD8+ TILs (p= 0.027) but not of Foxp3+ TILs (p= 0.455) and CD20+ TILs (p= 0.163). A high CD8+/HEV+ level was significantly associated with nodal metastasis (p= 0.048). In survival analysis, patients with high CD8+/HEV+ levels demonstrated the longest overall survival (OS) (p= 0.015). Furthermore, a high CD8+/HEV+ level was an independent prognostic factor in AGC (p= 0.011; hazard ratio (HR) = 0.435; 95% confidence interval (CI) = 0.245-0.837). HEVs were found to play an important role in antitumor immunity associated with CD8+ TILs in AGC. This analysis of HEVs and CD8+ TILs helps stratify patients with AGC and sheds light on tumor immunity.

引用

页码：1 / 12

页数：12

共 37 条

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