Successful treatment of myasthenia gravis with tacrolimus

被引：59
作者：
Evoli, A [1 ]
Di Schino, C [1 ]
Marsili, F [1 ]
Punzi, C [1 ]
机构：
[1] Univ Cattolica Sacro Cuore, Inst Neurol, I-00168 Rome, Italy
来源：
MUSCLE & NERVE | 2002年 / 25卷 / 01期
关键词：
cyclosporine; diabetes mellitus; HCV infection; myasthenia gravis; tacrolimus;
D O I：
10.1002/mus.10018
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Tacrolimus (FK-506) is a calcium-calcineurin inhibitor, successfully used in transplant recipients. We report the successful use of tacrolimus as a single immunosuppressant in a patient who had developed myasthenia gravis (MG) during interferon alpha treatment. In this case, the coexistence of hepatitis C and type 2 diabetes mellitus contraindicated the use of both steroids and azathioprine, and cyclosporine A, although effective, had induced renal failure. Tacrolimus proved to be effective in the treatment of MG, was not significantly hepatotoxic, and was less nephrotoxic than cyclosporine. (C) 2002 John Wiley & Sons, Inc.
引用
收藏
页码：111 / 114
页数：4
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