Transgenerational impact of DEHP on body weight of Drosophila

被引：23

作者：

Chen, Mei-Ying ^{[1
]}

Liu, Hsin-Ping ^{[2
,3
]}

Cheng, Jack ^{[5
,6
]}

Chiang, Su-Yin ^{[4
]}

Liao, Wing-Ping ^{[1
]}

Lin, Wei-Yong ^{[5
,6
,7
]}

机构：

[1] Natl Chung Hsing Univ, Dept Environm Engn, 145 Xingda Rd, Taichung 402, Taiwan

[2] China Med Univ, Coll Chinese Med, Grad Inst Acupuncture Sci, Taichung 40402, Taiwan

[3] Asia Univ, Dept Bioinformat & Med Engn, Taichung 41354, Taiwan

[4] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung 40402, Taiwan

[5] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung 40402, Taiwan

[6] China Med Univ Hosp, Dept Med Res, Taichung 90447, Taiwan

[7] China Med Univ, Brain Dis Res Ctr, Taichung 40402, Taiwan

来源：

CHEMOSPHERE | 2019年 / 221卷

关键词：

DEHP; Transgeneration; Obesity; Drosophila melanogaster; DI(2-ETHYLHEXYL) PHTHALATE DEHP; IN-UTERO; EXPOSURE; TOXICITY; METABOLITES; FERTILITY; EXCRETION; RECEPTOR; DUST; RATS;

D O I：

10.1016/j.chemosphere.2018.12.193

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bis(2-ethylhexyl) phthalate (DEHP) is the most typical plasticizer and an environmental endocrine disruptor (EDC). DEHP is known to influence offspring fertility, growth, and obesity. However, the role of the DEHP as a transgenerational obesogen is still controversial. In this study, we used fruit flies (Drosophila melanogaster) to investigate where the exposure period, doses, and exposed parental sex are critical to change the body weight of the offspring. We found long-term but not short-term, and high-dose but low-dose exposure resulted in significant change. Moreover, we found DEHP treatment on the father or mother Drosophila resulted in increased or decreased body weight of the offspring respectively. Our results demonstrated the heterogeneity of transgenerational impact of DEHP and highlighted the involvement of parental endocrine system in its role as an obesogen. (C) 2018 Published by Elsevier Ltd.

引用

页码：493 / 499

页数：7

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