Synthesis and fungicidal activity of substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols

被引：1

作者：

Popkov, S. V. ^{[1
]}

Makarenko, A. A. ^{[1
]}

Nikishin, G. I. ^{[2
]}

机构：

[1] DI Mendeleev Univ Chem Technol Russia, 9 Miusskaya Pl, Moscow 125047, Russia

[2] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2016年 / 65卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols; imidazole; spiro[4.5]-decan-6-one; triadimenol; 1,2,4-triazole; fungicidal activity; DRUG DESIGN; CHEMISTRY;

D O I：

10.1007/s11172-016-1331-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of halogen substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols were obtained from spiro[4.5]decan-6-one in three steps: Claisen-Schmidt condensation with substituted benzaldehydes, conversion of 7-benzylidenespiro[4.5]decan-6-ones to oxiranes by reaction with dimethylsulphonium methylide followed by ring opening of oxiranes with 1,2,4-triazole or imidazole. In vitro testing of fungicidal activity of synthesized compounds against seven phytopathogenic fungi showed, that a number of compounds are more active than triadimenol.

引用

页码：513 / 518

页数：6

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