Hepatoblastoma in a Mosaic Trisomy 18 Patient

被引：21

作者：

Pereira, Elaine Maria ^{[2
]}

Marion, Robert ^{[2
]}

Ramesh, K. H. ^{[3
]}

Kim, Jane S. ^{[4
]}

Ewart, Michelle ^{[3
]}

Ricafort, Rosanna ^{[1
]}

机构：

[1] Montefiore Med Ctr, Dept Pediat Hematol Oncol, Bronx, NY 10467 USA

[2] Montefiore Med Ctr, Dept Genet, Bronx, NY 10467 USA

[3] Montefiore Med Ctr, Dept Pathol, Bronx, NY 10467 USA

[4] Montefiore Med Ctr, Dept Radiol, Bronx, NY 10467 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2012年 / 34卷 / 04期

关键词：

hepatoblastoma; trisomy; 18; mosaic; cytogenetics; CHILDHOOD HEPATOBLASTOMA; ONCOLOGY-GROUP; CHILDREN; LIVER; GIRL; RISK;

D O I：

10.1097/MPH.0b013e3182459ee8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management approach resulted in a successful outcome; she remains disease free > 2 years after surgery. Along with presenting a literature review, this report demonstrates a favorable outcome in a mosaic trisomy 18 child with hepatoblastoma where tumor cells lacked a trisomy 18 karyotype.

引用

页码：E145 / E148

页数：4

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