Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers A pooled analysis of randomized trials

被引：8

作者：

Bryant, Kristina A. ^{[1
]}

McVernon, Jodie ^{[2
,3
]}

Marchant, Colin D. ^{[4
]}

Nolan, Terry ^{[2
,3
]}

Marshall, Gary S. ^{[1
]}

Richmond, Peter ^{[5
,6
]}

Marshall, Helen ^{[7
,8
]}

Nissen, Michael ^{[9
,10
]}

Lambert, Stephen B. ^{[9
,10
]}

Aris, Emmanuel ^{[11
]}

Mesaros, Narcisa ^{[11
]}

Miller, Jacqueline M. ^{[12
]}

机构：

[1] Univ Louisville, Louisville, KY 40292 USA

[2] Murdoch Childrens Res Inst, Vaccine & Immunisat Res Grp, Melbourne, Vic, Australia

[3] Univ Melbourne, Melbourne, Vic, Australia

[4] Boston Univ, Med Ctr, Boston, MA USA

[5] Univ Western Australia, Sch Paediat & Child Hlth, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia

[6] Princess Margaret Hosp Children, Perth, WA, Australia

[7] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia

[8] Womens & Childrens Hosp, Vaccinol & Immunol Res Trials Unit, Adelaide, SA, Australia

[9] Univ Queensland, Brisbane, Qld, Australia

[10] Royal Childrens Hosp, Queensland Childrens Med Res Inst, Queensland Paediat Infect Dis Lab, Brisbane, Qld, Australia

[11] GlaxoSmithKline Biol, Wavre, Belgium

[12] GlaxoSmithKline Biol, King Of Prussia, PA USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2012年 / 8卷 / 08期

关键词：

Haemophilus influenzae type b; Neisseria meningitidis serogroups C and Y; MMR; varicella; vaccination; toddlers; INFANTS; PERSISTENCE; HIBMENCY; ANTIBODY; AGE;

D O I：

10.4161/hv.20357

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A pooled analysis was conducted of 1,257 toddlers who received a fourth dose of Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) or Hib conjugate vaccine (Hib polysaccharide conjugated to N. meningitidis outer membrane protein) coadministered with measles-mumps-rubella (MMR) and varicella (VAR) vaccines (NCT00134719/NCT00289783). Noninferiority of immunological responses to MMR and VAR was demonstrated between groups and incidences of MMR- and VAR-specific solicited symptoms were similar, indicating that HibMenCY-TT can be coadministered with MMR and VAR.

引用

页码：1036 / 1041

页数：6

共 10 条

[1]

Advisory Committee on Immunization Practices, 2011, CHILD AD IMM SCHED

[2]

[Anonymous], 2009, ACTHIB PACK INS

[3] Immunogenicity and Safety of H influenzae Type b-N meningitidis C/Y Conjugate Vaccine in Infants [J].