No genetic linkage between multiple sclerosis and the interferon alpha/beta locus

被引：10

作者：

Bergkvist, M

Martinsson, T

Aman, P

SandbergWollheim, M

机构：

[1] UNIV LUND HOSP, DEPT CLIN GENET, S-22185 LUND, SWEDEN

[2] EAST HOSP, DEPT CLIN GENET, S-41685 GOTHENBURG, SWEDEN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1996年 / 65卷 / 02期

关键词：

multiple sclerosis; interferon; genetic linkage; DNA;

D O I：

10.1016/0165-5728(96)00018-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is probably caused by an interaction of genetic and environmental factors. The genetic component is reflected by a ten-fold higher concordance rate in monozygotic (27%) compared to dizygotic (3%) twin pairs. Treatment with interferon was recently reported to have a favorable effect in patients with relapsing-remitting MS. In the present familial study, we have investigated the possibility of a genetic association between the highly polymorphic Interferon alpha beta locus and the development of MS. Based on our data, we conclude that there is no linkage between the Interferon alpha beta locus and MS.

引用

页码：163 / 165

页数：3

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