Total Synthesis of (±)-Minfiensine via a Formal [3+2] Cycloaddition

被引：10

作者：

Zhang, Chao ^{[1
,2
]}

Ji, Wenzhi ^{[1
]}

Liu, Yahu A. ^{[3
]}

Song, Chun ^{[2
]}

Liao, Xuebin ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Pharmaceut Sci, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing 100084, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ, Jinan 250012, Shandong, Peoples R China

[3] Novartis Res Fdn, Genom Inst, Discovery Chem, San Diego, CA 92121 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 04期

关键词：

IMINIUM ION CYCLIZATION; CONCISE TOTAL-SYNTHESIS; AKUAMMILINE ALKALOIDS; VINYL HALIDES; CASCADE; CORE; PYRROLOINDOLINES; (+)-MINFIENSINE; MINFIENSINE; ACCESS;

D O I：

10.1021/acs.jnatprod.7b00873

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

(+/-)-Minfiensine (1) was synthesized in 10 steps in 26% overall yield with the 1,2,3,4-tetrahydro-9a,4-aiminoethanocarbazole core constructed through a [3+2] cycloaddition reaction between indole and an azaoxyallylic cation.

引用

页码：1065 / 1069

页数：5

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