Outcomes, complications, and economic impact of ABO-incompatible living kidney transplantation: A single-center Japanese cohort study

被引：9

作者：

Kakuta, Yoichi ^{[1
]}

Okumi, Masayoshi ^{[1
]}

Unagami, Kohei ^{[2
]}

Iizuka, Junpei ^{[1
]}

Takagi, Toshio ^{[1
]}

Ishida, Hideki ^{[2
]}

Tanabe, Kazunari ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Dept Urol, Tokyo, Japan

[2] Tokyo Womens Med Univ, Dept Organ Transplant Med, Tokyo, Japan

来源：

CLINICAL TRANSPLANTATION | 2019年 / 33卷 / 06期

关键词：

ABO-incompatibility; desensitization; immunosuppression; kidney transplantation; medical cost; DESENSITIZATION; RECIPIENTS; COST;

D O I：

10.1111/ctr.13591

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-transplantation. We included 65 ABO-ILKTs and 94 ABO-CLKTs in this retrospective analysis. The patient survival, graft survival, rejection incidence, and graft function were similar between ABO-CLKT and ABO-ILKT. The hospitalization costs for ABO-CLKT and ABO-ILKT were 26 544 +/- 4168 USD and 34 906 +/- 18 732 USD, respectively (P = 0.0001). Total 2-year medical costs were 77 117 +/- 15 609 USD and 85 325 +/- 33 997 USD for ABO-CLKT and ABO-ILKT, respectively, indicating that the medical costs of ABO-ILKT recipients were non-significantly higher than those of ABO-CLKT recipients at 2 years post-transplantation (P = 0.0866). ABO-ILKT and ABO-CLKT recipients showed similar infectious adverse events and complications. In conclusion, medical cost at 2 years post-transplantation, including transplant hospitalization cost, and the frequency of early complications were not significantly higher in the ABO-ILKT group than in the ABO-CLKT group. ABO-ILKT is an acceptable treatment for patients with ESRD and is comparable to ABO-CLKT not only in terms of outcomes but also in terms of medical cost.

引用

页数：8

共 25 条

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