Outcomes, complications, and economic impact of ABO-incompatible living kidney transplantation: A single-center Japanese cohort study

被引：9
作者：
Kakuta, Yoichi [1 ]
Okumi, Masayoshi [1 ]
Unagami, Kohei [2 ]
Iizuka, Junpei [1 ]
Takagi, Toshio [1 ]
Ishida, Hideki [2 ]
Tanabe, Kazunari [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Urol, Tokyo, Japan
[2] Tokyo Womens Med Univ, Dept Organ Transplant Med, Tokyo, Japan
来源：
CLINICAL TRANSPLANTATION | 2019年 / 33卷 / 06期
关键词：
ABO-incompatibility; desensitization; immunosuppression; kidney transplantation; medical cost; DESENSITIZATION; RECIPIENTS; COST;
D O I：
10.1111/ctr.13591
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-transplantation. We included 65 ABO-ILKTs and 94 ABO-CLKTs in this retrospective analysis. The patient survival, graft survival, rejection incidence, and graft function were similar between ABO-CLKT and ABO-ILKT. The hospitalization costs for ABO-CLKT and ABO-ILKT were 26 544 +/- 4168 USD and 34 906 +/- 18 732 USD, respectively (P = 0.0001). Total 2-year medical costs were 77 117 +/- 15 609 USD and 85 325 +/- 33 997 USD for ABO-CLKT and ABO-ILKT, respectively, indicating that the medical costs of ABO-ILKT recipients were non-significantly higher than those of ABO-CLKT recipients at 2 years post-transplantation (P = 0.0866). ABO-ILKT and ABO-CLKT recipients showed similar infectious adverse events and complications. In conclusion, medical cost at 2 years post-transplantation, including transplant hospitalization cost, and the frequency of early complications were not significantly higher in the ABO-ILKT group than in the ABO-CLKT group. ABO-ILKT is an acceptable treatment for patients with ESRD and is comparable to ABO-CLKT not only in terms of outcomes but also in terms of medical cost.
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页数：8
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