Type 1 diabetes: virus infection or autoimmune disease?

被引:36
作者
Fairweather, D [1 ]
Rose, NR
机构
[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA
关键词
D O I
10.1038/ni0402-338
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
What does Coxsackie virus have to do with diabetes? Evidence is emerging that insulin-producing β cells are highly susceptible to acute infection by Coxsackie virus if their production of interferon is inhibited, resulting in diabetes.
引用
收藏
页码:338 / 340
页数:4
相关论文
共 14 条
[1]   Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? [J].
Benoist, C ;
Mathis, D .
NATURE IMMUNOLOGY, 2001, 2 (09) :797-801
[2]   From infection to autoimmunity [J].
Fairweather, D ;
Kaya, Z ;
Shellam, GR ;
Lawson, CM ;
Rose, NR .
JOURNAL OF AUTOIMMUNITY, 2001, 16 (03) :175-186
[3]   Target cell defense prevents the development of diabetes after viral infection [J].
Flodström, M ;
Maday, A ;
Balakrishna, D ;
Cleary, MM ;
Yoshimura, A ;
Sarvetnick, N .
NATURE IMMUNOLOGY, 2002, 3 (04) :373-382
[4]   Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures [J].
Goodbourn, S ;
Didcock, L ;
Randall, RE .
JOURNAL OF GENERAL VIROLOGY, 2000, 81 :2341-2364
[5]   Noncytolytic control of viral infections by the innate and adaptive immune response [J].
Guidotti, LG ;
Chisari, FV .
ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :65-91
[6]   Pancreatic expression of interferon-γ protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis [J].
Horwitz, MS ;
La Cava, A ;
Fine, C ;
Rodriguez, E ;
Ilic, A ;
Sarvetnick, N .
NATURE MEDICINE, 2000, 6 (06) :693-697
[7]   Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry [J].
Horwitz, MS ;
Bradley, LM ;
Harbertson, J ;
Krahl, T ;
Lee, J ;
Sarvetnick, N .
NATURE MEDICINE, 1998, 4 (07) :781-785
[8]   Molecular mimicry: a critical look at exemplary instances in human diseases [J].
Rose, NR ;
Mackay, IR .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (04) :542-551
[9]   DEFINING CRITERIA FOR AUTOIMMUNE-DISEASES (WITEBSKY POSTULATES REVISITED) [J].
ROSE, NR ;
BONA, C .
IMMUNOLOGY TODAY, 1993, 14 (09) :426-429
[10]   Interferon-α-induced endogenous superantigen:: A model linking environment and autoimmunity [J].
Stauffer, Y ;
Marguerat, S ;
Meylan, F ;
Ucla, C ;
Sutkowski, N ;
Huber, B ;
Pelet, T ;
Conrad, B .
IMMUNITY, 2001, 15 (04) :591-601