Methylation of imidazopyrazine, imidazoquinoxaline, and pyrazoloquinoxaline through Suzuki-Miyaura cross coupling

被引：3

作者：

Karroum, Nour Bou ^{[1
,2
]}

Patinote, Cindy ^{[1
,3
]}

Deleuze-Masquefa, Carine ^{[1
]}

Moarbess, Georges ^{[2
]}

Diab-Assaf, Mona ^{[2
]}

Cuq, Pierre ^{[1
]}

Kassab, Issam ^{[2
]}

Bonnet, Pierre-Antoine ^{[1
]}

机构：

[1] Univ Montpellier, IBMM, CNRS, ENSCM, Montpellier, France

[2] Lebanese Univ, EDST, Tumorigenese & Pharmacol Antitumorale, BP 90656, Fanar Jdeideh, Lebanon

[3] Soc Accelerat Transfert Technol SATT AxLR, CSU, 950 Rue St Priest, F-34090 Montpellier, France

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 02期

关键词：

imidazo[1,2-a]pyrazine; imidazo[1,2-a]quinoxaline; pyrazolo[1,5-a]quinoxaline; methylation; Suzuki-Miyaura cross coupling; IN-VITRO; DERIVATIVES; ACIDS; INHIBITORS; ARYL; HALIDES;

D O I：

10.1007/s10593-018-2252-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Suzuki-Miyaura cross coupling is a versatile and powerful reaction for carbon-carbon bond formation which nevertheless requires optimization of conditions. While the coupling of arylboron derivatives with aryl or alkenyl halides has been widely explored, alkylation has attracted less attention. We describe herein the methylation of bromo derivatives of imidazopyrazine, imidazoquinoxaline, and pyrazoloquinoxaline having biologically interesting structures. As the challenging Suzuki-Miyaura reaction is highly substratedependent, the choices of the base, solvent, and additive are also discussed.

引用

页码：183 / 187

页数：5

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