Inflammatory Plasma Markers and Pancreatic Cancer Risk: A Prospective Study of Five U.S. Cohorts

被引：28

作者：

Bao, Ying ^{[1
]}

Giovannucci, Edward L. ^{[1
,6
,7
]}

Kraft, Peter ^{[5
,6
]}

Qian, Zhi Rong ^{[10
]}

Wu, Chen ^{[6
]}

Ogino, Shuji ^{[3
,6
,10
]}

Gaziano, J. Michael ^{[2
,14
]}

Stampfer, Meir J. ^{[1
,6
,7
]}

Ma, Jing ^{[1
,6
]}

Buring, Julie E. ^{[2
,4
,5
,6
]}

Sesso, Howard D. ^{[2
,5
,6
]}

Lee, I-Min ^{[2
,5
,6
]}

Rifai, Nader ^{[9
]}

Pollak, Michael N. ^{[11
]}

Jiao, Li ^{[12
]}

Lessin, Lawrence ^{[15
]}

Cochrane, Barbara B. ^{[13
]}

Manson, JoAnn E. ^{[1
,2
,6
,8
]}

Fuchs, Charles S. ^{[1
,10
]}

Wolpin, Brian M. ^{[1
,10
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[4] Dept Ambulatory Care & Prevent, Boston, MA USA

[5] Harvard Univ, Sch Med, Boston, MA 02115 USA

[6] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[7] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[8] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[9] Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA

[10] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[11] McGill Univ, Fac Med, Dept Oncol, Canc Prevent Res Unit, Montreal, PQ, Canada

[12] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[13] Univ Washington, Sch Nursing, Seattle, WA 98195 USA

[14] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Washington, DC USA

[15] Medstar Res Inst, Washington, DC USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2013年 / 22卷 / 05期

基金：

美国国家卫生研究院;

关键词：

C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; CARDIOVASCULAR-DISEASE; WOMENS HEALTH; INSULIN-RESISTANCE; DIABETES-MELLITUS; PHYSICAL-ACTIVITY; SERUM-LEVELS; OBESITY; MEN;

D O I：

10.1158/1055-9965.EPI-12-1458

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic inflammation may play a role in the development of pancreatic cancer. However, few prospective studies have examined the association between plasma inflammatory markers and pancreatic cancer risk. Therefore, we investigated the association of prediagnostic circulating C-reactive protein (CRP), interleukin-6 (IL-6), and TNF-alpha receptor II (TNF-alpha R2) with subsequent pancreatic cancer risk in a prospective, nested case-control study of 470 cases and 1,094 controls from Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, Women's Health Initiative, and Women's Health Study. The median follow-up time of cases was 7.2 years (range 1-26 years). No association was observed between plasma CRP, IL-6, and TNF-alpha R2 and the risk of pancreatic cancer. Comparing extreme quintiles, the multivariate ORs were 1.10 [95% confidence interval (CI), 0.74-1.63; P-trend = 0.81] for CRP, 1.19 (95% CI, 0.81-1.76; P-trend = 0.08) for IL-6, and 0.88 (95% CI, 0.58-1.33; P-trend = 0.57) for TNF-alpha R2. In conclusion, prediagnostic levels of circulating CRP, IL-6, and TNF-alpha R2 were not associated with the risk of pancreatic cancer, suggesting that systemic inflammation as measured by circulating inflammatory factors is unlikely to play a major role in the development of pancreatic cancer. (C) 2013 AACR.

引用

页码：855 / 861

页数：7

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