Neuropathology of Alzheimer's disease

被引：56
|
作者：
Mott, RT [1 ]
Hulette, CM [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
来源：
NEUROIMAGING CLINICS OF NORTH AMERICA | 2005年 / 15卷 / 04期
关键词：
D O I：
10.1016/j.nic.2005.09.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In 1907, Alois Alzheimer described the presence of plaques and neurofibrillary tangles in a demented patient. Currently, Alzheimer's disease is known to be the most common cause of dementia in elderly patients. In this article, we summarize the most important neuropathologic features of Alzheimer's disease, including amyloid plaques, neurofibrillary tangles, neuronal loss, synaptic depletion, cerebral amyloid angiopathy, Hirano bodies, and granulovacuolar degeneration. We also review the history and application of Alzheimer's disease diagnostic criteria.
引用
收藏
页码：755 / +
页数：12
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