Circular RNA in multiple myeloma: A new target for therapeutic intervention

被引：2

作者：

Ren, Hefei ^{[1
]}

Chen, Sai ^{[1
]}

Liu, Chang ^{[1
]}

Wu, Hongkun ^{[1
]}

Wang, Zhenhua ^{[1
]}

Zhang, Xiaomin ^{[1
]}

Ren, Jigang ^{[1
]}

Zhou, Lin ^{[1
]}

机构：

[1] Naval Med Univ, Shanghai Changzheng Hosp, Dept Lab Med, 415 Fengyang Rd, Shanghai 200003, Peoples R China

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2022年 / 238卷

基金：

中国国家自然科学基金; 芬兰科学院;

关键词：

Multiple myeloma; Circular RNA; Therapeutic intervention; Drug resistance; UP-REGULATION; BIOMARKER; PROMOTES; TRANSCRIPTION; PROGRESSION; MECHANISMS; DIAGNOSIS;

D O I：

10.1016/j.prp.2022.154129

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Circular RNAs (circRNAs) are RNA molecules with a stable closed-loop structure that are found in a variety of organisms. CircRNAs are highly stable and conserved, and they play important roles in transcriptional regulation and splicing. Multiple Myeloma (MM) is a malignant proliferative disease for which there are currently no effective and comprehensive treatments. Numerous circRNAs may contribute to the development and progres-sion of MM by acting as oncogenes or regulators. Due to the unique function of circRNAs, they have a high potential for regulating the biological functions (including proliferation and apoptosis) of MM cells, and their expression levels and molecular mechanism are closely related to their diagnostic value, therapeutic sensitivity, and clinical prognosis of MM patients. In this review, we aim to provide a detailed overview of the structure and function of circRNAs and demonstrate the potential therapeutic value and potential mechanism of circRNAs in MM via experiments and clinical trials.

引用

页数：9

共 96 条

[1] Armored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-β [J].