The cooperation of I-U-R (Industry-University-Research) is a way that our country builds a market-oriented innovation system. Now, the base statement of China Industry-Education-Research is well, but there still has lots of influencing factor, such as power, the distribution of benefits, investment and financing, risk, policy and many other issues. The distribution of benefits is the most important problem which restricts Industry-Education-Research development. This article attempts to construct long-term stability of Cooperative mechanism in order to promote research cooperation, technological innovation and co-ordinate regional resource.