Myeloid-Derived Suppressor Cells

被引:1450
作者
Gabrilovich, Dmitry I. [1 ]
机构
[1] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19085 USA
关键词
TUMOR-BEARING MICE; T-CELLS; IMMUNE-RESPONSE; LUNG-CANCER; BONE-MARROW; CLINICAL-RELEVANCE; MULTIPLE-MYELOMA; DIFFERENTIATION; NEUTROPHILS; CARCINOMA;
D O I
10.1158/2326-6066.CIR-16-0297
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Myeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. This process is epitomized by myeloid-derived suppressor cells (MDSC). These cells are closely related to neutrophils and monocytes. MDSCs are not present in the steady state of healthy individuals and appear in cancer and in pathologic conditions associated with chronic inflammation or stress. These cells have emerged as an important contributor to tumor progression. Ample evidence supports a key role for MDSCs in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases. MDSCs have a fascinating biology and are implicated in limiting the effects of cancer immunotherapy. Therefore, targeting these cells may represent an attractive therapeutic opportunity. (C) 2016 AACR.
引用
收藏
页码:3 / 8
页数:6
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