Analytical and Theranostic Applications of Gold Nanoparticles and Multifunctional Nanocomposites

被引：141

作者：

Khlebtsov, Nikolai ^{[1
,2
]}

Bogatyrev, Vladimir ^{[1
,2
]}

Dykman, Lev ^{[1
]}

Khlebtsov, Boris ^{[1
]}

Staroverov, Sergey ^{[1
]}

Shirokov, Alexander ^{[1
]}

Matora, Larisa ^{[1
]}

Khanadeev, Vitaly ^{[1
]}

Pylaev, Timofey ^{[1
]}

Tsyganova, Natalia ^{[3
]}

Terentyuk, Georgy ^{[2
,3
]}

机构：

[1] IBPPM RAS, Saratov, Russia

[2] Saratov NG Chernyshevskii State Univ, Saratov, Russia

[3] Ulyanovsk State Univ, Ulyanovsk, Russia

来源：

THERANOSTICS | 2013年 / 3卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

Gold nanoparticles; multifunctional nanocomposites; immunoassay; DNA detection; cell bioimaging; mycobacteria; Azospirillum brasilense; photodynamic and photothermal therapy; placental barrier; materno-embryonic transfer of gold nanoparticles;

D O I：

10.7150/thno.5716

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gold nanoparticles (GNPs) and GNP-based multifunctional nanocomposites are the subject of intensive studies and biomedical applications. This minireview summarizes our recent efforts in analytical and theranostic applications of engineered GNPs and nanocomposites by using plasmonic properties of GNPs and various optical techniques. Specifically, we consider analytical biosensing; visualization and bioimaging of bacterial, mammalian, and plant cells; photodynamic treatment of pathogenic bacteria; and photothermal therapy of xenografted tumors. In addition to recently published reports, we discuss new data on dot immunoassay diagnostics of mycobacteria, multiplexed immunoelectron microscopy analysis of Azospirillum brasilense, materno-embryonic transfer of GNPs in pregnant rats, and combined photodynamic and photothermal treatment of rat xenografted tumors with gold nanorods covered by a mesoporous silica shell doped with hematoporphyrin.

引用

页码：167 / 180

页数：14

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