Synthesis and biological evaluation of new symmetric curcumin derivatives

被引：52

作者：

Sribalan, Rajendran ^{[1
]}

Kirubavathi, Maruthan ^{[1
]}

Banuppriya, Govindharaj ^{[1
]}

Padmini, Vediappen ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 19期

关键词：

Curcumin; Acetamides; Anti-inflammatory; Cytotoxicity; Antioxidant; POTENTIAL ANTICANCER AGENTS; PROSTATE CANCER AGENTS; ANTIINFLAMMATORY AGENTS; SIGNALING PATHWAY; ANTITUMOR AGENTS; ANALOGS; ANTIOXIDANT; DESIGN; EXPLORATION;

D O I：

10.1016/j.bmcl.2015.07.088

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel curcumin bisacetamides aiming of enriching their biological activities have been synthesized. The synthesized compounds were screened for their in vitro antioxidant, anti-inflammatory and cytotoxic activities. All the compounds exhibited potent to good anti-inflammatory, antioxidant and noteworthy cytotoxic activities. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4282 / 4286

页数：5

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