[60]Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity

被引：479
|
作者：
Gharbi, N
Pressac, M
Hadchouel, M
Szwarc, H
Wilson, SR
Moussa, F
机构：
[1] Univ Paris 11, Fac Pharm, CNRS, UMR 8612, F-92296 Chatenay Malabry, France
[2] Univ Paris 05, Fac Pharm, Lab Endocrinol, F-75006 Paris, France
[3] CHU Kremlin Bicetre, INSERM, U347, F-94265 Le Kremlin Bicetre, France
[4] NYU, Dept Chem, New York, NY 10003 USA
来源：
NANO LETTERS | 2005年 / 5卷 / 12期
关键词：
D O I：
10.1021/nl051866b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present work, we report the effects Of C-60-pretreatments on acute carbon tetrachloride intoxication in rats, a classical model for studying free-radical-mediated liver injury. Our results show that aqueous C-60 suspensions prepared without using any polar organic solvent not only have no acute or subacute toxicity in rodents but they also protect their livers in a dose-dependent manner against free-radical damage. To be sure, according to histopathological examinations and biological tests, pristine C-60 can be considered as a powerful liver-protective agent.
引用
收藏
页码：2578 / 2585
页数：8
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