Translation initiation factors: a weak link in plant RNA virus infection

被引：334
作者：
Robaglia, C [1 ]
Caranta, C
机构：
[1] Univ Aix Marseille 2, CNRS, CEA, Lab Genet & Biophys Plantes,Fac Sci Luminy, F-13009 Marseille, France
[2] INRA, Unite Genet & Ameliorat Plantes, F-84143 Montfavet, France
来源：
TRENDS IN PLANT SCIENCE | 2006年 / 11卷 / 01期
关键词：
D O I：
10.1016/j.tplants.2005.11.004
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Recessive resistance genes against plant viruses have been recognized for a long time but their molecular nature has only recently been linked to components of the eukaryotic translation initiation complex. Translation initiation factors, and particularly the elF4E and elF4G protein families, were found to be essential determinants in the outcome of RNA virus infections. Viruses affected by these genes belong mainly to polyviruses; natural viral resistance mechanisms as well as mutagenesis analysis in Arabidopsis all converged to identify the same set of translation initiation factors. Their role in plant resistance against RNA viruses remains to be elucidated. Although the interaction with the protein synthesis machinery is probably a key element for successful RNA virus infection, other possible mechanisms will also be discussed.
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收藏
页码：40 / 45
页数：6
相关论文
共 39 条
[1]   FUNCTION OF THE P86 SUBUNIT OF EUKARYOTIC INITIATION-FACTOR (ISO)4F AS A MICROTUBULE-ASSOCIATED PROTEIN IN PLANT-CELLS [J].
BOKROS, CL ;
HUGDAHL, JD ;
KIM, HH ;
HANESWORTH, VR ;
VANHEERDEN, A ;
BROWNING, KS ;
MOREJOHN, LC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) :7120-7124
[2]   Mutations in Pea seedborne mosaic virus genome-linked protein VPg alter pathotype-specific virulence in Pisum sativum [J].
Borgstrom, B ;
Johansen, IE .
MOLECULAR PLANT-MICROBE INTERACTIONS, 2001, 14 (06) :707-714
[3]  
BROWNING KS, 1992, J BIOL CHEM, V267, P10096
[4]   CAP-INDEPENDENT ENHANCEMENT OF TRANSLATION BY A PLANT POTYVIRUS 5' NONTRANSLATED REGION [J].
CARRINGTON, JC ;
FREED, DD .
JOURNAL OF VIROLOGY, 1990, 64 (04) :1590-1597
[5]   High-throughput screening for induced point mutations [J].
Colbert, T ;
Till, BJ ;
Tompa, R ;
Reynolds, S ;
Steine, MN ;
Yeung, AT ;
McCallum, CM ;
Comai, L ;
Henikoff, S .
PLANT PHYSIOLOGY, 2001, 126 (02) :480-484
[6]   Translation initiation factors eIF4E and eIFiso4E are required for polysome formation and regulate plant growth in tobacco [J].
Combe, JP ;
Petracek, ME ;
van Eldik, G ;
Meulewaeter, F ;
Twell, D .
PLANT MOLECULAR BIOLOGY, 2005, 57 (05) :749-760
[7]   Molecular characterization of a Melon necrotic spot virus strain that overcomes the resistance in melon and nonhost plants [J].
Diaz, JA ;
Nieto, C ;
Moriones, E ;
Truniger, V ;
Aranda, MA .
MOLECULAR PLANT-MICROBE INTERACTIONS, 2004, 17 (06) :668-675
[8]   The Arabidopsis eukaryotic initiation factor (iso)4E is dispensable for plant growth but required for susceptibility to potyviruses [J].
Duprat, A ;
Caranta, C ;
Revers, F ;
Menand, B ;
Browning, KS ;
Robaglia, C .
PLANT JOURNAL, 2002, 32 (06) :927-934
[9]   GENES FOR RESISTANCE TO PLANT-VIRUSES [J].
FRASER, RSS .
CRC CRITICAL REVIEWS IN PLANT SCIENCES, 1986, 3 (03) :257-294
[10]   Cap-independent translation conferred by the 5′ leader of tobacco etch virus is eukaryotic initiation factor 4G dependent [J].
Gallie, DR .
JOURNAL OF VIROLOGY, 2001, 75 (24) :12141-12152
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