Recent developments and current concepts in medulloblastoma

被引：76

作者：

Gerber, N. U. ^{[1
]}

Mynarek, M. ^{[2
]}

von Hoff, K. ^{[2
]}

Friedrich, C. ^{[2
]}

Resch, A. ^{[2
]}

Rutkowski, S. ^{[2
]}

机构：

[1] Univ Childrens Hosp, Dept Oncol, CH-8032 Zurich, Switzerland

[2] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Hematol & Oncol, D-20246 Hamburg, Germany

来源：

CANCER TREATMENT REVIEWS | 2014年 / 40卷 / 03期

关键词：

(MeSH): Medulloblastoma; Brain neoplasms; Child; Cancer; Therapy; Molecular targeted therapy; EARLY-CHILDHOOD MEDULLOBLASTOMA; CRANIOSPINAL RADIATION-THERAPY; HEDGEHOG PATHWAY INHIBITOR; MALIGNANT BRAIN-TUMORS; STEM-CELL RESCUE; CHILDRENS-ONCOLOGY; ADJUVANT CHEMOTHERAPY; YOUNG-CHILDREN; NONMETASTATIC MEDULLOBLASTOMA; POSTOPERATIVE CHEMOTHERAPY;

D O I：

10.1016/j.ctrv.2013.11.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Medulloblastoma is the most common malignant brain tumor of childhood. While prognosis has significantly improved in the last decades with multimodal therapy including surgery, radiotherapy, and chemotherapy, one third of patients still succumb to their disease. Further research is needed to find more efficient treatment strategies for prognostically unfavorable patient groups and to minimize long-term sequelae of tumor treatment. This review gives a summary of the current state of treatment concepts including an outlook on the near future. We describe recent advances in the understanding of molecular mechanisms, their potential impact on risk stratification in upcoming clinical trials, and perspectives for the clinical implementation of targeted therapies. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：356 / 365

页数：10

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