The role of the prolactin receptor pathway in the pathogenesis of glioblastoma: what do we know so far?

被引:9
作者
Asad, Antonela S. [1 ]
Nicola Candia, Alejandro J. [1 ]
Gonzalez, Nazareno [1 ]
Zuccato, Camila F. [1 ]
Seilicovich, Adriana [1 ,2 ]
Candolfi, Marianela [1 ]
机构
[1] Univ Buenos Aires, Fac Med, UBA CONICET, Inst Invest Biomed INBIOMED, Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Med, Dept Biol Celular & Histol, Buenos Aires, DF, Argentina
关键词
Glioblastoma; prolactin; prolactin receptor; therapeutic target; CENTRAL-NERVOUS-SYSTEM; BREAST-CANCER; PROGESTERONE-RECEPTORS; CELL-PROLIFERATION; SIGNAL TRANSDUCER; ESTROGEN-RECEPTOR; TYROSINE KINASE; PRL RECEPTOR; N-CADHERIN; EXPRESSION;
D O I
10.1080/14728222.2020.1821187
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Prolactin (PRL) and its receptor (PRLR) have been associated with the development of hormone-dependent tumors and have been detected in glioblastoma (GBM) biopsies. GBM is the most common and aggressive primary brain tumor in adults and the prognosis for patients is dismal; hence researchers are exploring the PRLR pathway as a therapeutic target in this disease. Areas covered: This paper explores the effects of PRLR activation on the biology of GBM, the correlation between PRL and PRLR expression and GBM progression and survival in male and female patients. Finally, we discuss how a better understanding of the PRLR pathway may allow the development of novel treatments for GBM. Expert opinion: We propose PRL and PRLR as potential prognosis biomarkers and therapeutic targets in GBM. Local administration of PRLR inhibitors using gene therapy may offer a beneficial strategy for targeting GBM cells disseminated in the non-neoplastic brain; however, efficacy and safety require careful and extensive evaluation. The data depicted herein underline the need to (i) improve our understanding of sexual dimorphism in GBM, and (ii) develop accurate preclinical models that take into consideration different hormonal contexts, specific genetic alterations, and tumor grades.
引用
收藏
页码:1121 / 1133
页数:13
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