Optimization of Hydrogenolysis of Glycerol to 1,2-Propanediol

Based on statistical experimental design methodology, the single-response optimization of technological parameters of glycerol hydrogenolysis to 1,2-propanediol was performed. The independent factors (technological parameters) considered were the following: hydrogenolysis temperature, glycerol concentration in water, concentration of catalyst, and reaction time. The technological parameters were selected based on our previous, preliminary studies carried out by the single variable function method. The single-response optimization was performed using the rotatable uniform design. The optimized functions were glycerol conversion and selectivity of transformation to 1,2-propanediol.