A hybrid small-diameter tube fabricated from decellularized aortic intima-media and electrospun fiber for artificial small-diameter blood vessel

被引:20
|
作者
Wu, Pingli [1 ,3 ]
Nakamura, Naoko [1 ,4 ]
Morita, Hiroko [1 ]
Nam, Kwangwoo [1 ]
Fujisato, Toshiya [2 ]
Kimura, Tsuyoshi [1 ]
Kishida, Akio [1 ]
机构
[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Tokyo 1010062, Japan
[2] Osaka Inst Technol, Dept Biomed Engn, Osaka 5358585, Japan
[3] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
[4] Shibaura Inst Technol, Dept Biosci & Engn, Saitama, Japan
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
small-diameter blood vessel; electrospinning; mechanical compliance; decellularized aortic intima-media; SEGMENTED POLYURETHANE; VASCULAR GRAFTS; ELASTOMER; SCAFFOLDS;
D O I
10.1002/jbm.a.36631
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Hybrid small-diameter tubes were fabricated by wrapping decellularized aortic intima-media sheets around a tubular stainless steel mandrel with diameter 4 mm, and then by coating with electrospun segmented polyurethane. The synthetic coat was deposited uniformly to a thickness of about 0.5-3.5 mu m depending on the duration of electrospinning. Resistance to luminal pressure, burst strength, and stiffness increased with the thickness of the electrospun coat, suggesting that the synthetic fabric reinforces the reconstructed acellular aortic intima-media. Human umbilical vein endothelial cells seeded on the inner surface acquired flagstone morphology, while normal human dermal fibroblasts seeded on the outer surface proliferated well and partly migrated into deeper layers. Collectively, the data suggest that reinforcing decellularized aortic intima-media with electrospun fibers generates a small-diameter hybrid blood vessel with good biocompatibility and suitable mechanical properties. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1064-1070, 2019.
引用
收藏
页码:1064 / 1070
页数:7
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