Glomerulotubular Balance, Tubuloglomerular Feedback, and Salt Homeostasis

被引：82
作者：
Thomson, Scott C. [1 ]
Blantz, Roland C.
机构：
[1] Univ Calif San Diego, Dept Med, Div Nephrol & Hypertens, San Diego, CA 92161 USA
来源：
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 12期
关键词：
D O I：
10.1681/ASN.2007121326
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The homeostasis of NaCl is critical to complex organisms with closed blood systems. Kidneys regulate this salt excretion by modulating the rapport between glomeruli and tubules. The tubules respond to glomeruli with glomerulotubular balance, whereas glomeruli respond to tubules through tubuloglomerular feedback. These relationships are dynamic, mysterious, and amenable to mathematical analyses. The biology underlining what is known about these interactions is observational, fragmentary, and somewhat inconclusive. Discussed here is a simple tethering of these interrelated concepts.
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收藏
页码：2272 / 2275
页数：4
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