The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

被引：96
作者：
Knobbe, C. B. [1 ]
Lapin, V. [1 ,2 ]
Suzuki, A. [3 ]
Mak, T. W. [1 ,2 ]
机构：
[1] Univ Toronto, Campbell Family Inst Breast Canc Res, Toronto, ON, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
[3] Kyushu Univ, Med Inst Bioregulat, Div Embryon & Genet Engn, Fukuoka 812, Japan
来源：
ONCOGENE | 2008年 / 27卷 / 41期
基金：
加拿大健康研究院;
关键词：
PTEN; mouse; conditional gene-targeting; KO;
D O I：
10.1038/onc.2008.238
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In 1997, PTEN (phosphatase and tensin homologue deleted on chromosome 10, 10q23.3) was identified as an important tumor suppressor gene that is inactivated in a wide variety of human cancers. Ever since, PTEN's function has been extensively studied, and huge progress has been made in understanding PTEN's role in normal physiology and disease. In this review, we will systematically summarize the important data that have been gained from gene inactivation studies in mice and will put these data into physiological context using a tissue-by-tissue approach. We will cover mice exhibiting complete and constitutive inactivation of Pten as well as a large number of strains in which Pten has been conditionally deleted in specific tissues. We hope to highlight not only the tumor suppressive function of Pten but also its roles in embryogenesis and in the maintenance of the normal physiological functions of many organ systems.
引用
收藏
页码：5398 / 5415
页数：18
相关论文
共 108 条
[1]   Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver [J].
Abel, ED ;
Peroni, O ;
Kim, JK ;
Kim, YB ;
Boss, O ;
Hadro, E ;
Minnemann, T ;
Shulman, GI ;
Kahn, BB .
NATURE, 2001, 409 (6821) :729-733
[2]   Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function [J].
Anzelon, AN ;
Wu, H ;
Rickert, RC .
NATURE IMMUNOLOGY, 2003, 4 (03) :287-294
[3]   Somatic mutation of PTEN in bladder carcinoma [J].
Aveyard, JS ;
Skilleter, A ;
Habuchi, T ;
Knowles, MA .
BRITISH JOURNAL OF CANCER, 1999, 80 (5-6) :904-908
[4]   Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease [J].
Backman, SA ;
Stambolic, V ;
Suzuki, A ;
Haight, J ;
Elia, A ;
Pretorius, J ;
Tsao, MS ;
Shannon, P ;
Bolon, B ;
Ivy, GO ;
Mak, TW .
NATURE GENETICS, 2001, 29 (04) :396-403
[5]   Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten [J].
Backman, SA ;
Ghazarian, D ;
So, K ;
Sanchez, O ;
Wagner, KU ;
Hennighausen, L ;
Suzuki, A ;
Tsao, MS ;
Chapman, WB ;
Stambolic, V ;
Mak, TW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (06) :1725-1730
[6]   PTEN function in mammalian cell size regulation [J].
Backman, SA ;
Stambolic, V ;
Mak, TW .
CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (05) :516-522
[7]   Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations [J].
Butler, MG ;
Dasouki, MJ ;
Zhou, XP ;
Talebizadeh, Z ;
Brown, M ;
Takahashi, TN ;
Miles, JH ;
Wang, CH ;
Stratton, R ;
Pilarski, R ;
Eng, C .
JOURNAL OF MEDICAL GENETICS, 2005, 42 (04) :318-321
[8]   S6k1 is not required for Pten-deficient neuronal hypertrophy [J].
Chalhoub, Nader ;
Kozma, Sara C. ;
Baker, Suzanne J. .
BRAIN RESEARCH, 2006, 1100 :32-41
[9]   Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways [J].
Crackower, MA ;
Oudit, GY ;
Kozieradzki, I ;
Sarao, R ;
Sun, H ;
Sasaki, T ;
Hirsch, E ;
Suzuki, A ;
Shioi, T ;
Irie-Sasaki, J ;
Sah, R ;
Cheng, HYM ;
Rybin, VO ;
Lembo, G ;
Fratta, L ;
Oliveira-dos-Santos, AJ ;
Benovic, JL ;
Kahn, CR ;
Izumo, S ;
Steinberg, SF ;
Wymann, MP ;
Backx, PH ;
Penninger, JM .
CELL, 2002, 110 (06) :737-749
[10]   Pathological and molecular aspects of prostate cancer [J].
DeMarzo, AM ;
Nelson, WG ;
Isaacs, WB ;
Epstein, JI .
LANCET, 2003, 361 (9361) :955-964
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