E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions

被引：71

作者：

Carneiro, Patricia ^{[1
]}

Sofia Fernandes, Maria ^{[1
]}

Figueiredo, Joana ^{[1
,2
]}

Caldeira, Joana ^{[1
,3
]}

Carvalho, Joana ^{[1
,2
]}

Pinheiro, Hugo ^{[1
]}

Leite, Marina ^{[1
]}

Melo, Soraia ^{[1
]}

Oliveira, Patricia ^{[1
]}

Simoes-Correia, Joana ^{[1
,4
]}

Jose Oliveira, Maria ^{[1
,2
]}

Carneiro, Fatima ^{[1
,2
,5
]}

Figueiredo, Ceu ^{[1
,2
]}

Paredes, Joana ^{[1
,2
]}

Oliveira, Carla ^{[1
,2
]}

Seruca, Raquel ^{[1
,2
]}

机构：

[1] Univ Porto, Inst Mol Pathol & Immunol, IPATIMUP, P-4200465 Oporto, Portugal

[2] Univ Porto, Fac Med, P-4200465 Oporto, Portugal

[3] INEB Inst Biomed Engn, NewTherapies Grp, Oporto, Portugal

[4] Ctr Ophthalmol & Vis Sci IBILI, P-3000548 Coimbra, Portugal

[5] Ctr Hosp Sao Joao, Oporto, Portugal

来源：

FEBS LETTERS | 2012年 / 586卷 / 18期

关键词：

E-cadherin; Adhesion; Tumour; Gastric cancer; HDGC; Signalling; Invasion; HELICOBACTER-PYLORI INFECTION; EPITHELIAL-MESENCHYMAL TRANSITIONS; GERMLINE MISSENSE MUTATIONS; TRANSCRIPTION FACTOR SNAIL; GROWTH-FACTOR RECEPTOR; REGULATES E-CADHERIN; ADHESION MOLECULE; PROMOTER METHYLATION; DOWN-REGULATION; MEDIATED ADHESION;

D O I：

10.1016/j.febslet.2012.07.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

E-cadherin plays a major role in cell-cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2981 / 2989

页数：9

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